About: Diprenorphine

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Diprenorphine (brand name Revivon; former developmental code name M5050), also known as diprenorfin, is a non-selective, high-affinity, weak partial agonist of the μ- (MOR), κ- (KOR), and δ-opioid receptor (DOR) (with equal affinity) which is used in veterinary medicine as an opioid antagonist. It is used to reverse the effects of super-potent opioid analgesics such as etorphine and carfentanil that are used for tranquilizing large animals. The drug is not approved for use in humans.

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rdf:type	Thing dul:ChemicalObject chemical substance Drug yago:Abstraction100002137 yago:Agent114778436 yago:Alcohol107884567 yago:Beverage107881800 yago:CausalAgent100007347 yago:Chemical114806838 yago:Compound114818238 yago:Drug103247620 yago:DrugOfAbuse103248958 yago:Element114840755 yago:Fluid114939900 yago:Food100021265 yago:Liquid114940386 yago:Material114580897 yago:Matter100020827 yago:OrganicCompound114727670 yago:Part113809207 yago:Phenol114989545 yago:PhysicalEntity100001930 yago:Quintessence114847103 yago:Relation100031921 drug yago:Substance100019613 yago:Substance100020090 yago:WikicatAlcohols yago:WikicatEthers yago:WikicatPhenols umbel-rc:DrugProduct
rdfs:label	Diprenorphin (de) Diprenorphine (en) Diprénorphine (fr) 地利洛非 (zh)
rdfs:comment	Diprenorphin (Revivon, M5050) ist ein Opioid-Antagonist. Es wird eingesetzt, um die Wirkung extrem potenter Opioide, wie Etorphin oder Carfentanyl aufzuheben, die in der Tiermedizin eingesetzt werden, um große Tiere zu betäuben. Diprenorphin ist der stärkste kommerziell verfügbare Opioidantagonist. Es wird benutzt, um Tiere, die mit den genannten Opioiden betäubt worden sind, wieder aufzuwecken. Weil Diprenorphin eine zum Teil auch agonistische Wirkung hat, wird es nicht beim Menschen angewandt, wo Naloxon oder Naltrexon Mittel der Wahl sind.Die Wirkungsstärke als Antagonist wird mit 100-mal der von (N-Allylnormorphin, einem schon seit Langem nicht mehr eingesetzten Opioidantagonisten) angegeben. In Deutschland sind keine Tierarzneimittel auf der Basis von Diprenorphin zugelassen. (de) La diprénorphine, ou diprénorfine, est un agoniste partiel faible non sélectif dont l'affinité très élevée est égale pour les récepteurs opioïdes mu (μ), delta (δ) et kappa (κ). Elle est employée en médecine vétérinaire comme antagoniste des opioïdes pour stopper l'effet des sédatifs très puissants comme l'étorphine et le carfentanil utilisés pour tranquilliser les gros animaux. L'usage de cette molécule sur les humains n'est pas autorisé. (fr) 地利洛非也称为二丙诺啡，是（MOR），（KOR）和阿片受体（DOR）（三者具有相同的亲和力）的非选择性，高亲和力，弱部分激动剂，同时在兽医学中用作。它用于逆转超强效阿片类镇痛药的作用，例如用于镇静大型动物的和。该药物未被批准用于人类。地利洛非是市场上最强的阿片类拮抗剂（作为拮抗剂的效力比纳洛芬高100倍），并且用于逆转非常强的阿片类物质的作用是，其结合亲和力如此之高以至于纳洛酮不能有效或可靠地逆转麻醉作用。这些超强效的阿片类药物，除了丁丙诺啡以外（由于其部分激动作用而具有改善的安全性），因为人体剂量太小难以正确测量，因此不会用于人体。因此过量服用的风险会导致致命的呼吸抑制。然而，常规阿片类衍生物的镇静强度不足以使大型动物（如大象和犀牛）迅速镇静，因此埃托啡和卡芬太尼等药物可用于此目的。因为地利洛非是阿片受体的弱部分激动剂而不是沉默拮抗剂，可以在没有其他足够剂量的阿片类药物的情况下产生一些阿片类药物作用。此外，由于具有KOR的部分激动作用，它似乎相对于MOR具有显着更大的内在活性，因此地利洛非可以产生镇静作用，并且在人类中也可以产生幻觉。 (zh) Diprenorphine (brand name Revivon; former developmental code name M5050), also known as diprenorfin, is a non-selective, high-affinity, weak partial agonist of the μ- (MOR), κ- (KOR), and δ-opioid receptor (DOR) (with equal affinity) which is used in veterinary medicine as an opioid antagonist. It is used to reverse the effects of super-potent opioid analgesics such as etorphine and carfentanil that are used for tranquilizing large animals. The drug is not approved for use in humans. (en)
foaf:depiction
dcterms:subject	4,5-Epoxymorphinans Ethers Phenols Semisynthetic opioids Tertiary alcohols Kappa-opioid receptor agonists Mu-opioid receptor antagonists Kappa-opioid receptor antagonists Delta-opioid receptor antagonists
Wikipage page ID	10977211 (xsd:integer)
Wikipage revision ID	1090160742 (xsd:integer)
Link from a Wikipage to another Wikipage	Carfentanil Partial agonist Veterinary medicine Intrinsic activity Δ-opioid receptor 4,5-Epoxymorphinans Ethers Phenols Semisynthetic opioids Tertiary alcohols Overdose Opioid receptor Nalorphine Naloxone Opioid antagonist Kappa-opioid receptor agonists Mu-opioid receptor antagonists Hallucination Buprenorphine Analgesic Kappa-opioid receptor antagonists Etorphine Μ-opioid receptor Delta-opioid receptor antagonists Affinity (pharmacology) Binding selectivity Tranquilizer Opioid Κ-opioid receptor Sedation Silent antagonist Respiratory depression
sameAs	Diprenorphine Diprenorphine Diprenorphine Diprenorphine Diprenorphine Diprenorphine Diprenorphine Diprenorphine Diprenorphine Diprenorphine Diprenorphine
dbp:wikiPageUsesTemplate	dbt:Citation_needed dbt:Drugbox dbt:Reflist dbt:Short_description dbt:Cascite

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