About: Diproqualone

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An Entity of Type : umbel-rc:DrugProduct, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)
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Diproqualone is a quinazolinone class GABAergic and is an analogue of methaqualone developed in the late 1950s by a team at Nogentaise de Produits Chimique. It was marketed primarily in France and some other European countries. It has sedative, anxiolytic, antihistamine and analgesic properties, resulting from its agonist activity at the β subtype of the GABAa receptor, antagonist activity at all histamine receptors, inhibition of thecyclooxygenase-1 enzyme, and possibly its agonist activity at both the sigma-1 receptor and sigma-2 receptor (the function of these receptors and their clinical relevance has not yet been determined). Diproqualone is used primarily for the treatment of inflammatory pain associated with osteoarthritis and rheumatoid arthritis, and more rarely for treating insom

Attributes	Values
rdf:type	Thing dul:ChemicalObject chemical substance Drug yago:WikicatAnalgesics yago:WikicatSedatives yago:Agent114778436 yago:Analgesic102707683 yago:CausalAgent100007347 yago:Drug103247620 yago:DrugOfAbuse103248958 yago:Matter100020827 yago:Medicine103740161 yago:PhysicalEntity100001930 drug yago:Sedative104166553 yago:Substance100020090 umbel-rc:DrugProduct
rdfs:label	Diproqualone (en)
rdfs:comment	Diproqualone is a quinazolinone class GABAergic and is an analogue of methaqualone developed in the late 1950s by a team at Nogentaise de Produits Chimique. It was marketed primarily in France and some other European countries. It has sedative, anxiolytic, antihistamine and analgesic properties, resulting from its agonist activity at the β subtype of the GABAa receptor, antagonist activity at all histamine receptors, inhibition of thecyclooxygenase-1 enzyme, and possibly its agonist activity at both the sigma-1 receptor and sigma-2 receptor (the function of these receptors and their clinical relevance has not yet been determined). Diproqualone is used primarily for the treatment of inflammatory pain associated with osteoarthritis and rheumatoid arthritis, and more rarely for treating insom (en)
foaf:depiction
dcterms:subject	Analgesics Diols GABAA receptor positive allosteric modulators Lactams Sedatives Quinazolinones
Wikipage page ID	10044144 (xsd:integer)
Wikipage revision ID	1091772450 (xsd:integer)
Link from a Wikipage to another Wikipage	Quinazolinone Analgesics Diols GABAA receptor positive allosteric modulators Lactams Sedatives Mebroqualone Mecloqualone Cloroqualone Gabaergic dbr:Gamma-Aminobutyric_acid Antihistamine Anxiolytic GABAA receptor Afloqualone Analgesic Etaqualone Ethenzamide Histamine receptor Quinazolinones Methaqualone Methylmethaqualone Sedative Sigma-2 receptor dbr:Sigma-1_receptor PTGS1
sameAs	Diproqualone Diproqualone Diproqualone Diproqualone Diproqualone Diproqualone Diproqualone Diproqualone
dbp:wikiPageUsesTemplate	dbt:Drugbox dbt:GABAAR_PAMs dbt:Sedatives dbt:Short_description dbt:Cascite dbt:Chemspidercite dbt:Drugbankcite dbt:Fdacite dbt:Stdinchicite dbt:Sedative-stub
thumbnail	wiki-commons:Special:FilePath/Diproqualone.svg?width=300
ATC prefix	none (en)
c	12 (xsd:integer)
CAS number	36518 (xsd:integer)
ChemSpiderID	57691 (xsd:integer)
H	14 (xsd:integer)
IUPAC name	3 (xsd:integer)
molecular weight	234.251000 (xsd:double)
n	2 (xsd:integer)
O	3 (xsd:integer)
PubChem	64112 (xsd:integer)
SMILES	O=C1C2=CC=CC=C2N=CN1CCO (en)
StdInChI	1 (xsd:integer)
StdInChIKey	NTGLQWGMESPVBV-UHFFFAOYSA-N (en)
UNII	QY7HLH8V4L (en)
verifiedrevid	443773846 (xsd:integer)
Watchedfields	changed (en)
width	200 (xsd:integer)
has abstract	Diproqualone is a quinazolinone class GABAergic and is an analogue of methaqualone developed in the late 1950s by a team at Nogentaise de Produits Chimique. It was marketed primarily in France and some other European countries. It has sedative, anxiolytic, antihistamine and analgesic properties, resulting from its agonist activity at the β subtype of the GABAa receptor, antagonist activity at all histamine receptors, inhibition of thecyclooxygenase-1 enzyme, and possibly its agonist activity at both the sigma-1 receptor and sigma-2 receptor (the function of these receptors and their clinical relevance has not yet been determined). Diproqualone is used primarily for the treatment of inflammatory pain associated with osteoarthritis and rheumatoid arthritis, and more rarely for treating insomnia, anxiety and neuralgia. Diproqualone is the only analogue of methaqualone that is still in widespread clinical use, due to its useful anti-inflammatory and analgesic effects in addition to the sedative and anxiolytic actions common to other drugs of this class. There are still some concerns about the potential of diproqualone for abuse and overdose, and so it is not sold as a pure drug but only as the camphosulfonate salt in combination mixtures with other medicines such as ethenzamide. (en)
gold:hypernym	GABAergic
prov:wasDerivedFrom	wikipedia-en:Diproqualone?oldid=1091772450&ns=0
page length (characters) of wiki page	3433 (xsd:nonNegativeInteger)
CAS number	36518-02-2
FDA UNII code	QY7HLH8V4L
PubChem	64112
foaf:isPrimaryTopicOf	wikipedia-en:Diproqualone
is Link from a Wikipage to another Wikipage of	Quinazolinone

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