Drake's Assault on Panama also known as the Defence of Panama was a military event that took place in January 1596 during the Anglo–Spanish War. An English expedition under the command of Francis Drake and Thomas Baskerville attacked the Spanish Main via Nombre de Dios in order to cross the isthmus of Panama. Ravaged with dysentery and other diseases the English were repelled and defeated. Drake would die of the former and the expedition was forced to retreat back to England all the while harassed by the Spanish.