About: ESAT-6

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ESAT-6 or Early Secreted Antigenic Target 6 kDa, is produced by Mycobacterium tuberculosis, it is a secretory protein and potent T cell antigen. It is used in tuberculosis diagnosis by the whole blood interferon γ test QuantiFERON-TB Gold, in conjunction with CFP-10 and .

Attributes	Values
rdf:type	Thing Biomolecule Biomolecule Protein protein
rdfs:label	ESAT-6 (en)
rdfs:comment	ESAT-6 or Early Secreted Antigenic Target 6 kDa, is produced by Mycobacterium tuberculosis, it is a secretory protein and potent T cell antigen. It is used in tuberculosis diagnosis by the whole blood interferon γ test QuantiFERON-TB Gold, in conjunction with CFP-10 and . (en)
foaf:name	6 kDa early secretory antigenic target (en)
name	6 (xsd:integer)
foaf:depiction
dcterms:subject	Bacterial proteins Tuberculosis
Wikipage page ID	11561227 (xsd:integer)
Wikipage revision ID	1105807726 (xsd:integer)
Link from a Wikipage to another Wikipage	Antigen Joyoti Basu QuantiFERON Bacterial proteins Tuberculosis Signal transduction CFP-10 Mycobacterium tuberculosis T cell Secretory protein Tuberculosis diagnosis TLR4 Interferon γ test dbr:TB7.7
sameAs	ESAT-6 ESAT-6 ESAT-6
dbp:wikiPageUsesTemplate	dbt:Protein-stub dbt:Infobox_protein dbt:Actinobacteria-stub
thumbnail	wiki-commons:Special:FilePath/Mycobacterium_tuberculosis_MEB_(1).jpg?width=300
symbol	esxA (en)
UniProt	P0A564 (en)
has abstract	ESAT-6 or Early Secreted Antigenic Target 6 kDa, is produced by Mycobacterium tuberculosis, it is a secretory protein and potent T cell antigen. It is used in tuberculosis diagnosis by the whole blood interferon γ test QuantiFERON-TB Gold, in conjunction with CFP-10 and . ESAT-6 has been shown to directly bind to the TLR2 receptor, inhibiting downstream signal transduction. It has also been studied that the inactivation of ESAT-6 leads to decreased virulence of M. Tuberculosis. Secretion of the ESAT-6 protein is one of the main determining factors in the virulence of the M. Tuberculosis. ESAT-6 has more commonly become a marker for the TB diagnosis and treatment. There is also the use of the ESAT increase the production of virulent factors that cause for the increase in pathogenicity of TB. ESAT-6 is one of the main proteins that is inhibited in the production of vaccines for M. Tuberculosis with the combination of the increased antigenic factors agβ5-A and the agβ5-C. There are studies that are currently trying to connect the linkage between ESAT-6 and the epithelial cells that are in the lungs, which has shown the dependence on the induction of the IL-8 promoter. (en)
EntrezGene	886209 (xsd:integer)
PDB	3 (xsd:integer)
gold:hypernym	Protein
EntrezGene	886209
PDB ID	3FAV
UniProt	P0A564
prov:wasDerivedFrom	wikipedia-en:ESAT-6?oldid=1105807726&ns=0
page length (characters) of wiki page	7419 (xsd:nonNegativeInteger)
Symbol	esxA
foaf:isPrimaryTopicOf	wikipedia-en:ESAT-6
is Link from a Wikipage to another Wikipage of	Joyoti Basu Interferon gamma release assay QuantiFERON Latent tuberculosis Bacterial secretion system CFP-10
is foaf:primaryTopic of	wikipedia-en:ESAT-6

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