Edwin Sisterton Clarke FRCP (18 June 1919 – 11 April 1996) was a British neurologist and medical historian, best remembered for his role as Director of the Wellcome Institute for the History of Medicine, when he succeeded Noël Poynter and oversaw the transfer of the Wellcome museum to the Science museum, helped establish an intercalated BSc degree in the history of medicine for medical students and edited the journal Medical History. His publications included a series of monographs on the history of the neurosciences.