Egnell Creek is a tributary of the Hackett River in northwest part of the province of British Columbia, Canada. It flows generally southwest about 24 km (15 mi) to join the Hackett River near the Hackett's confluence with the Sheslay River, which in turn is a tributary of the Inklin River, the main southeast fork of the Taku River. is located near the creek's mouth, as is the historic locality known as Egnell or Sheslay, once a telegraph station on the Yukon Telegraph Line. Egnell Creek is in the traditional territory of the Tlingit Taku River Tlingit First Nation and the Tahltan people.