About: Emylcamate

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Emylcamate (marketed as Striatran by Merck) is an anxiolytic and muscle relaxant. It was patented in the US in 1961 (US Patent 2,972,564) and advertised for the treatment of anxiety and tension. It was claimed to be superior to meprobamate, which was the market leader at the time. It is no longer prescribed. A study of the drug's effects in mice was done in 1959. It concluded that at 50 mg/kg emylcamate gave a 63% decrease in motor activity compared with meprobamate's 32% decrease, a doubling in effective potency. The therapeutic index in mice was also established:

Attributes	Values
rdf:type	Thing dul:ChemicalObject chemical substance Drug yago:WikicatAnxiolytics yago:WikicatMuscleRelaxants yago:Agent114778436 yago:CausalAgent100007347 yago:Drug103247620 yago:DrugOfAbuse103248958 yago:Matter100020827 yago:Medicine103740161 yago:MinorTranquilizer103771443 yago:MuscleRelaxant103800001 yago:PhysicalEntity100001930 yago:PsychotropicAgent104017429 yago:Relaxant104072811 drug yago:Sedative-hypnotic104166841 yago:Sedative104166553 yago:Substance100020090 yago:Tranquilizer104470232 umbel-rc:DrugProduct
rdfs:label	Emylcamate (en)
rdfs:comment	Emylcamate (marketed as Striatran by Merck) is an anxiolytic and muscle relaxant. It was patented in the US in 1961 (US Patent 2,972,564) and advertised for the treatment of anxiety and tension. It was claimed to be superior to meprobamate, which was the market leader at the time. It is no longer prescribed. A study of the drug's effects in mice was done in 1959. It concluded that at 50 mg/kg emylcamate gave a 63% decrease in motor activity compared with meprobamate's 32% decrease, a doubling in effective potency. The therapeutic index in mice was also established: (en)
foaf:depiction
dcterms:subject	Carbamates GABAA receptor positive allosteric modulators Muscle relaxants Anxiolytics
Wikipage page ID	3493584 (xsd:integer)
Wikipage revision ID	1120611035 (xsd:integer)
Link from a Wikipage to another Wikipage	Carbamates GABAA receptor positive allosteric modulators Muscle relaxants Anxiolytic Therapeutic index Muscle relaxant Anxiolytics Median lethal dose Effective dose (pharmacology) Meprobamate Merck & Co.
Link from a Wikipage to an external page	http://www.biam2.org/www/Sub2770.html http://www.revistapsiqrs.org.br/administracao/arquivos/10-698-olhando_para_tras.pdf http://ctdbase.org/detail.go%3Ftype=chem&acc=C100111 https://web.archive.org/web/20060721024711/http:/www.revistapsiqrs.org.br/administracao/arquivos/10-698-olhando_para_tras.pdf
sameAs	Emylcamate Emylcamate Emylcamate Emylcamate Emylcamate Emylcamate Emylcamate Emylcamate
dbp:wikiPageUsesTemplate	dbt:Cite_journal dbt:Cite_web dbt:Drugbox dbt:GABAAR_PAMs dbt:Musculoskeletal-drug-stub dbt:Refbegin dbt:Refend dbt:Reflist dbt:Short_description dbt:Cascite dbt:Chemspidercite dbt:Drugbankcite dbt:Ebicite dbt:Fdacite dbt:Keggcite dbt:Stdinchicite dbt:Anxiolytics dbt:Anxiolytic-stub
thumbnail	wiki-commons:Special:FilePath/Emylcamate.svg?width=300
ATC suffix	BC03 (en)
ATC prefix	N05 (en)
c	7 (xsd:integer)
CAS number	78 (xsd:integer)
ChEBI	134769 (xsd:integer)
ChEMBL	2104208 (xsd:integer)
ChemSpiderID	6278 (xsd:integer)
DrugBank	DB13572 (en)
H	15 (xsd:integer)
IUPAC name	3 (xsd:integer)
KEGG	D07317 (en)
n	1 (xsd:integer)
O	2 (xsd:integer)
PubChem	6526 (xsd:integer)
SMILES	O=CN (en)
StdInChI	1 (xsd:integer)
StdInChIKey	SLWGJZPKHAXZQL-UHFFFAOYSA-N (en)
UNII	KCJ747D3R4 (en)
Verifiedfields	changed (en)
verifiedrevid	455055546 (xsd:integer)
width	150 (xsd:integer)
has abstract	Emylcamate (marketed as Striatran by Merck) is an anxiolytic and muscle relaxant. It was patented in the US in 1961 (US Patent 2,972,564) and advertised for the treatment of anxiety and tension. It was claimed to be superior to meprobamate, which was the market leader at the time. It is no longer prescribed. A study of the drug's effects in mice was done in 1959. It concluded that at 50 mg/kg emylcamate gave a 63% decrease in motor activity compared with meprobamate's 32% decrease, a doubling in effective potency. The therapeutic index in mice was also established: Emylcamate also has a faster intra-parenteral onset than meprobamate, 3 minutes compared with 35. (en)
gold:hypernym	Relaxant
prov:wasDerivedFrom	wikipedia-en:Emylcamate?oldid=1120611035&ns=0
page length (characters) of wiki page	3731 (xsd:nonNegativeInteger)
CAS number	78-28-4

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