About: Enoyl-CoA hydratase

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Enoyl-CoA hydratase (ECH) or crotonase is an enzyme EC 4.2.1.17 that hydrates the double bond between the second and third carbons on 2-trans/cis-enoyl-CoA: ECH is essential to metabolizing fatty acids in beta oxidation to produce both acetyl CoA and energy in the form of ATP.

Attributes	Values
rdf:type	Thing Biomolecule Biomolecule Protein protein umbel-rc:ProteinMolecule
rdfs:label	Enoyl-CoA hydratase (en) Énoyl-coenzyme A hydratase (fr) 엔오일-CoA 수화효소 (ko)
rdfs:comment	L'énoyl-CoA hydratase est une lyase de la superfamille des crotonases qui catalyse la réaction d'hydratation en deuxième étape de la β-oxydation : trans-2,3-déshydroacyl-CoA + H2O L-3-hydroxyacyl-CoA Il s'agit d'une enzyme constituée d'un hexamère de sous-unités qui rend la catalyse très efficace. Énoyl-CoA hydratase (fr) 엔오일-CoA 수화효소(ECH,Enoyl-CoA hydratase) 또는 크로토네이스(crotonase)는 기하 이성질체인 2- 트랜스 / 시스-엔오일-CoA에서 두 번째와 세 번째 탄소 사이의 이중 결합을 수화시키는 효소이다. > > (ko) Enoyl-CoA hydratase (ECH) or crotonase is an enzyme EC 4.2.1.17 that hydrates the double bond between the second and third carbons on 2-trans/cis-enoyl-CoA: ECH is essential to metabolizing fatty acids in beta oxidation to produce both acetyl CoA and energy in the form of ATP. (en)
foaf:name	enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase (en)
name	enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase (en)
foaf:depiction
dcterms:subject	EC 4.2.1
Wikipage page ID	8381542 (xsd:integer)
Wikipage revision ID	1100756461 (xsd:integer)
Link from a Wikipage to another Wikipage	Carbons Proton Base (chemistry) Beta oxidation Double bond E1cB-elimination reaction EC 4.2.1 Chemical reaction Energy Enzyme Stereoisomer Fumarase Active site Catalyzes Adenosine triphosphate Amino acids Fat Fatty acids Reaction rate Residue (chemistry) Acid Metabolizing Reaction mechanism Syn addition Water Hexameric protein Glutamate Acetyl CoA Triglycerol Β-oxidation dbr:Β-carbon
sameAs	Enoyl-CoA hydratase Enoyl-CoA hydratase Enoyl-CoA hydratase Enoyl-CoA hydratase Enoyl-CoA hydratase Enoyl-CoA hydratase Enoyl-CoA hydratase Enoyl-CoA hydratase
dbp:wikiPageUsesTemplate	dbt:Carbon-oxygen_lyases dbt:Clear dbt:EnzExplorer dbt:Enzymes dbt:MeshName dbt:Portal_bar dbt:Reflist dbt:Lipid_metabolism_enzymes dbt:Leucine_metabolism_in_humans dbt:Protein
thumbnail	wiki-commons:Special:FilePath/enzyme_hexamer.png?width=300
OMIM	607037 (xsd:integer)
AltSymbols	ECHD (en)
caption	Enoyl-CoA hydratase hexamer from a rat with active site in orange and substrate in red. (en)
ECnumber	4.200000 (xsd:double)
symbol	EHHADH (en)
UniProt	Q08426 (en)
has abstract	Enoyl-CoA hydratase (ECH) or crotonase is an enzyme EC 4.2.1.17 that hydrates the double bond between the second and third carbons on 2-trans/cis-enoyl-CoA: ECH is essential to metabolizing fatty acids in beta oxidation to produce both acetyl CoA and energy in the form of ATP. ECH of rats is a hexameric protein (this trait is not universal, but human enzyme is also hexameric), which leads to the efficiency of this enzyme as it has 6 active sites. This enzyme has been discovered to be highly efficient, and allows people to metabolize fatty acids into energy very quickly. In fact this enzyme is so efficient that the rate for short chain fatty acids is equivalent to that of diffusion-controlled reactions. (en) L'énoyl-CoA hydratase est une lyase de la superfamille des crotonases qui catalyse la réaction d'hydratation en deuxième étape de la β-oxydation : trans-2,3-déshydroacyl-CoA + H2O L-3-hydroxyacyl-CoA Il s'agit d'une enzyme constituée d'un hexamère de sous-unités qui rend la catalyse très efficace. Énoyl-CoA hydratase (fr) 엔오일-CoA 수화효소(ECH,Enoyl-CoA hydratase) 또는 크로토네이스(crotonase)는 기하 이성질체인 2- 트랜스 / 시스-엔오일-CoA에서 두 번째와 세 번째 탄소 사이의 이중 결합을 수화시키는 효소이다. > > (ko)
Arm	q (en)
band	26.300000 (xsd:double)
Chromosome	3 (xsd:integer)
EntrezGene	1962 (xsd:integer)
HGNCid	3247 (xsd:integer)
LocusSupplementaryData	-q28 (en)
RefSeq	NM_001966 (en)
locus supplementary data	-q28
gold:hypernym	Enzyme
arm	q
band	26.3
chromosome	3
EntrezGene	1962
HGNCid	3247
RefSeq	NM_001966
UniProt	Q08426
prov:wasDerivedFrom	wikipedia-en:Enoyl-CoA_hydratase?oldid=1100756461&ns=0

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