Epstein–Barr virus (EBV) latent membrane protein 2 (LMP2) are two viral proteins of the Epstein–Barr virus. LMP2A/LMP2B are transmembrane proteins that act to block tyrosine kinase signaling. LMP2A is a transmembrane protein that inhibits normal B-cell signal transduction by mimicking an activated B-cell receptor (BCR). The N-terminus domain of LMP2A is tyrosine phosphorylated and associates with Src family protein tyrosine kinases (PTKs) as well as spleen tyrosine kinase (Syk). PTKs and Syk are associated with BCR signal transduction.
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| - Proteína latente de la membrana 2 del virus Epstein–Barr (es)
- Epstein–Barr virus latent membrane protein 2 (en)
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| - Epstein–Barr virus (EBV) latent membrane protein 2 (LMP2) are two viral proteins of the Epstein–Barr virus. LMP2A/LMP2B are transmembrane proteins that act to block tyrosine kinase signaling. LMP2A is a transmembrane protein that inhibits normal B-cell signal transduction by mimicking an activated B-cell receptor (BCR). The N-terminus domain of LMP2A is tyrosine phosphorylated and associates with Src family protein tyrosine kinases (PTKs) as well as spleen tyrosine kinase (Syk). PTKs and Syk are associated with BCR signal transduction. (en)
- EBV proteína latente de la membrana 2 (LMP-2) se refiere a dos proteínas virales asociadas con el virus de Epstein-Barr. LMP-2A/LMP-2B son proteínas transmembranales que actúan para bloquear la señalización de tirosina quinasa. Se cree que actúan para inhibir la activación del ciclo lítico viral. Se desconoce si LMP-2B se requiere para la transformación mediada por el crecimiento de VEB, mientras que diferentes grupos han informado de que la alternativa es LMP-2A , o no es necesario para la transformación. (es)
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| - Epstein–Barr virus (EBV) latent membrane protein 2 (LMP2) are two viral proteins of the Epstein–Barr virus. LMP2A/LMP2B are transmembrane proteins that act to block tyrosine kinase signaling. LMP2A is a transmembrane protein that inhibits normal B-cell signal transduction by mimicking an activated B-cell receptor (BCR). The N-terminus domain of LMP2A is tyrosine phosphorylated and associates with Src family protein tyrosine kinases (PTKs) as well as spleen tyrosine kinase (Syk). PTKs and Syk are associated with BCR signal transduction. (en)
- EBV proteína latente de la membrana 2 (LMP-2) se refiere a dos proteínas virales asociadas con el virus de Epstein-Barr. LMP-2A/LMP-2B son proteínas transmembranales que actúan para bloquear la señalización de tirosina quinasa. Se cree que actúan para inhibir la activación del ciclo lítico viral. Se desconoce si LMP-2B se requiere para la transformación mediada por el crecimiento de VEB, mientras que diferentes grupos han informado de que la alternativa es LMP-2A , o no es necesario para la transformación. (es)
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