About: Estradiol mustard

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Estradiol mustard, also known as chlorphenacyl estradiol diester, as well as estradiol 3,17β-bis(4-(bis(2-chloroethyl)amino)phenyl)acetate, is a synthetic, steroidal estrogen and cytostatic antineoplastic agent and a chlorphenacyl nitrogen mustard-coupled estrogen ester that was never marketed. It is selectively distributed into estrogen receptor (ER)-positive tissues such as ER-expressing tumors like those seen in breast and prostate cancers. For this reason, estradiol mustard and other cytostatic-linked estrogens like estramustine phosphate have reduced toxicity relative to non-linked nitrogen mustard cytostatic antineoplastic agents. However, they may stimulate breast tumor growth due to their inherent estrogenic activity and are said to be devoid of major therapeutic efficacy in breast

Attributes	Values
rdf:type	Thing dul:ChemicalObject chemical substance Drug drug
rdfs:label	Estradiol mustard (en)
rdfs:comment	Estradiol mustard, also known as chlorphenacyl estradiol diester, as well as estradiol 3,17β-bis(4-(bis(2-chloroethyl)amino)phenyl)acetate, is a synthetic, steroidal estrogen and cytostatic antineoplastic agent and a chlorphenacyl nitrogen mustard-coupled estrogen ester that was never marketed. It is selectively distributed into estrogen receptor (ER)-positive tissues such as ER-expressing tumors like those seen in breast and prostate cancers. For this reason, estradiol mustard and other cytostatic-linked estrogens like estramustine phosphate have reduced toxicity relative to non-linked nitrogen mustard cytostatic antineoplastic agents. However, they may stimulate breast tumor growth due to their inherent estrogenic activity and are said to be devoid of major therapeutic efficacy in breast (en)
foaf:depiction
dcterms:subject	Abandoned drugs Prodrugs Synthetic estrogens Nitrogen mustards Antineoplastic drugs Chloroethyl compounds Estradiol esters
Wikipage page ID	51812133 (xsd:integer)
Wikipage revision ID	1120786397 (xsd:integer)
Link from a Wikipage to another Wikipage	List of estrogen esters Nitrogen mustard Breast Breast cancer List of hormonal cytostatic antineoplastic agents Abandoned drugs Prodrugs Synthetic estrogens Estrogen (medication) Estrogen ester Steroid Phenyl group Prostate cancer Acyl group Tumor Distribution (pharmacology) Cytostatic Nitrogen mustards Estramustine phosphate Estrogen receptor Cell growth Antineoplastic drugs Chloroethyl compounds Chlorine Estradiol esters Toxicity Chemotherapeutic agent Antineoplastic agent Synthetic compound
sameAs	Estradiol mustard Estradiol mustard Estradiol mustard
dbp:wikiPageUsesTemplate	dbt:Antineoplastic-drug-stub dbt:Drugbox dbt:Estrogen_receptor_modulators dbt:Genito-urinary-drug-stub dbt:Reflist dbt:Short_description dbt:Steroid-stub dbt:Estradiol
thumbnail	wiki-commons:Special:FilePath/Estradiol_mustard.svg?width=300
c	42 (xsd:integer)
CAS number	22966 (xsd:integer)
ChEBI	82520 (xsd:integer)
ChEMBL	1697793 (xsd:integer)
ChemSpiderID	29294 (xsd:integer)
Cl	4 (xsd:integer)
class	Estrogen (medication) Estrogen ester Chemotherapeutic agent
H	50 (xsd:integer)
IUPAC name	[-3-[2-[4-[Bisamino]phenyl]acetyl]oxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] 2-[4-[bisamino]phenyl]acetate (en)
n	2 (xsd:integer)
O	4 (xsd:integer)
PubChem	31586 (xsd:integer)
SMILES	C[C@]12CC[C@H]3[C@H]CCC5=C3C=CCOCCC6=CC=CNCCCl (en)
StdInChI	1 (xsd:integer)
StdInChIKey	LRSFXIJGHRPOQQ-VZRQQIPSSA-N (en)
synonyms	NSC-112259; Chlorphenacyl estradiol diester; Estradiol 3,17β-bisacetate (en)
UNII	GEO3F3A4K1 (en)
width	250 (xsd:integer)
has abstract	Estradiol mustard, also known as chlorphenacyl estradiol diester, as well as estradiol 3,17β-bis(4-(bis(2-chloroethyl)amino)phenyl)acetate, is a synthetic, steroidal estrogen and cytostatic antineoplastic agent and a chlorphenacyl nitrogen mustard-coupled estrogen ester that was never marketed. It is selectively distributed into estrogen receptor (ER)-positive tissues such as ER-expressing tumors like those seen in breast and prostate cancers. For this reason, estradiol mustard and other cytostatic-linked estrogens like estramustine phosphate have reduced toxicity relative to non-linked nitrogen mustard cytostatic antineoplastic agents. However, they may stimulate breast tumor growth due to their inherent estrogenic activity and are said to be devoid of major therapeutic efficacy in breast cancer, although estramustine phosphate has been approved for and is used (almost exclusively) in the treatment of prostate cancer. (en)
prov:wasDerivedFrom	wikipedia-en:Estradiol_mustard?oldid=1120786397&ns=0
page length (characters) of wiki page	4855 (xsd:nonNegativeInteger)
CAS number	22966-79-6
ChEBI	82520
ChEMBL	1697793
FDA UNII code	GEO3F3A4K1
PubChem	31586
class	Estrogen (medication) Estrogen ester Chemotherapeutic agent
foaf:isPrimaryTopicOf	wikipedia-en:Estradiol_mustard
is Link from a Wikipage to another Wikipage of	List of estrogen esters List of hormonal cytostatic antineoplastic agents Estramustine phosphate Chlorphenacyl estradiol diester NSC-112259 NSC112259 NSC 112259
is Wikipage redirect of	Chlorphenacyl estradiol diester NSC-112259 NSC112259

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