About: Etirinotecan pegol     Goto   Sponge   NotDistinct   Permalink

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Etirinotecan pegol (trade name Onzeald) is a drug developed by Nektar Therapeutics for the treatment of certain kinds of breast cancer with brain metastases. The European Medicines Agency refused to grant it a marketing authorisation in 2017.

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rdf:type
rdfs:label
  • Etirinotecan pegol (en)
rdfs:comment
  • Etirinotecan pegol (trade name Onzeald) is a drug developed by Nektar Therapeutics for the treatment of certain kinds of breast cancer with brain metastases. The European Medicines Agency refused to grant it a marketing authorisation in 2017. (en)
foaf:depiction
  • http://commons.wikimedia.org/wiki/Special:FilePath/Etirinotecan_pegol.svg
dcterms:subject
Wikipage page ID
Wikipage revision ID
Link from a Wikipage to another Wikipage
sameAs
dbp:wikiPageUsesTemplate
thumbnail
ATC suffix
  • CE03 (en)
ATC prefix
  • L01 (en)
CAS number
DrugBank
  • DB14951 (en)
elimination half-life
excretion
  • mostly via kidneys (en)
KEGG
  • D10367 (en)
molecular weight
routes of administration
synonyms
  • NKTR-102 (en)
tradename
  • Onzeald (en)
UNII
  • LJ16641SFT (en)
has abstract
  • Etirinotecan pegol (trade name Onzeald) is a drug developed by Nektar Therapeutics for the treatment of certain kinds of breast cancer with brain metastases. The European Medicines Agency refused to grant it a marketing authorisation in 2017. It works as a topoisomerase I inhibitor. Chemically, it consists of four units of irinotecan (a topoisomerase I inhibitor in use since the late 1990s) linked by carboxymethyl glycine and polyethylene glycol (PEG) chains to a central pentaerythritol ether, resulting in a much longer biological half-life (38 days) than that of irinotecan. It is formulated as a dihydrochloride and with 1.2 units of trifluoroacetate. (en)
Chemical Formula
  • C153H176N20O36[C8H16O4]n (en)
metabolites
  • irinotecan and its metabolites (en)
protein bound
  • none (en)
chemical formula
  • C153H176N20O36[C8H16O4]n (n≈113)
prov:wasDerivedFrom
page length (characters) of wiki page
alternative name
  • Onzeald (en)
CAS number
  • 848779-32-8
DrugBank
  • DB14951
FDA UNII code
  • LJ16641SFT
KEGG
  • D10367
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