About: FG-8205

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FG-8205 (L-663,581) is an imidazobenzodiazepine derivative related to bretazenil, which acts as a partial agonist at GABAA receptors, with slight selectivity for the α1-containing subtype. In animal tests it has anxiolytic and anticonvulsant effects but with little sedation or ataxia produced.

Attributes	Values
rdf:type	Thing dul:ChemicalObject chemical substance Drug yago:WikicatBenzodiazepines yago:Agent114778436 yago:Benzodiazepine102830852 yago:CausalAgent100007347 yago:Drug103247620 yago:DrugOfAbuse103248958 yago:Matter100020827 yago:Medicine103740161 yago:MinorTranquilizer103771443 yago:MuscleRelaxant103800001 yago:PhysicalEntity100001930 yago:PsychotropicAgent104017429 yago:Relaxant104072811 drug yago:Sedative-hypnotic104166841 yago:Sedative104166553 yago:Substance100020090 yago:Tranquilizer104470232
rdfs:label	FG-8205 (en) FG-8205 (it)
rdfs:comment	FG-8205 (L-663,581) is an imidazobenzodiazepine derivative related to bretazenil, which acts as a partial agonist at GABAA receptors, with slight selectivity for the α1-containing subtype. In animal tests it has anxiolytic and anticonvulsant effects but with little sedation or ataxia produced. (en) L'FG-8205 è uno psicofarmaco appartenente alla categoria delle ed è un analogo del bretazenil; esso agisce come un agonista parziale dei recettori GABA A, con leggera selettività per il sottotipo α1. Nei test sugli animali ha effetti ansiolitici e anticonvulsivanti ma con poca sedazione o atassia prodotta. (it)
foaf:depiction
dct:subject	GABAA receptor positive allosteric modulators Isopropyl compounds Oxadiazoles Imidazobenzodiazepines
Wikipage page ID	32813641 (xsd:integer)
Wikipage revision ID	1120043607 (xsd:integer)
Link from a Wikipage to another Wikipage	Partial agonist Benzodiazepine Bretazenil Anticonvulsant GABAA receptor positive allosteric modulators Isopropyl compounds Oxadiazoles Anxiolytic Imidazobenzodiazepines
sameAs	FG-8205 FG-8205 FG-8205 FG-8205 FG-8205 FG-8205 FG-8205
dbp:wikiPageUsesTemplate	dbt:Drugbox dbt:GABAAR_PAMs dbt:Nervous-system-drug-stub dbt:Reflist dbt:Short_description dbt:Cascite dbt:Chemspidercite dbt:Drugbankcite dbt:Ebicite dbt:Fdacite dbt:Stdinchicite dbt:Benzodiazepines
thumbnail	wiki-commons:Special:FilePath/FG-8205.svg?width=300
c	17 (xsd:integer)
CAS number	122384 (xsd:integer)
ChEMBL	307202 (xsd:integer)
ChemSpiderID	114837 (xsd:integer)
Cl	1 (xsd:integer)
H	16 (xsd:integer)
IUPAC name	7 (xsd:integer)
n	5 (xsd:integer)
O	2 (xsd:integer)
PubChem	129710 (xsd:integer)
SMILES	Clc4cccc3n2cncc2CNC (en)
StdInChI	1 (xsd:integer)
StdInChIKey	SEWXZWMBVGJJPG-UHFFFAOYSA-N (en)
UNII	7 (xsd:integer)
Verifiedfields	changed (en)
verifiedrevid	461098708 (xsd:integer)
Watchedfields	changed (en)
width	200 (xsd:integer)
has abstract	FG-8205 (L-663,581) is an imidazobenzodiazepine derivative related to bretazenil, which acts as a partial agonist at GABAA receptors, with slight selectivity for the α1-containing subtype. In animal tests it has anxiolytic and anticonvulsant effects but with little sedation or ataxia produced. (en) L'FG-8205 è uno psicofarmaco appartenente alla categoria delle ed è un analogo del bretazenil; esso agisce come un agonista parziale dei recettori GABA A, con leggera selettività per il sottotipo α1. Nei test sugli animali ha effetti ansiolitici e anticonvulsivanti ma con poca sedazione o atassia prodotta. (it)
prov:wasDerivedFrom	wikipedia-en:FG-8205?oldid=1120043607&ns=0
page length (characters) of wiki page	3821 (xsd:nonNegativeInteger)
CAS number	122384-14-9
ChEMBL	307202
FDA UNII code	7V0I080855
PubChem	129710
foaf:isPrimaryTopicOf	wikipedia-en:FG-8205
is Link from a Wikipage to another Wikipage of	List of benzodiazepines L-663,581
is Wikipage redirect of	L-663,581
is foaf:primaryTopic of	wikipedia-en:FG-8205

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