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Fast atom bombardment (FAB) is an ionization technique used in mass spectrometry in which a beam of high energy atoms strikes a surface to create ions. It was developed by Michael Barber at the University of Manchester in 1980. When a beam of high energy ions is used instead of atoms (as in secondary ion mass spectrometry), the method is known as liquid secondary ion mass spectrometry (LSIMS). In FAB and LSIMS, the material to be analyzed is mixed with a non-volatile chemical protection environment, called a matrix, and is bombarded under vacuum with a high energy (4000 to 10,000 electron volts) beam of atoms. The atoms are typically from an inert gas such as argon or xenon. Common matrices include glycerol, thioglycerol, 3-nitrobenzyl alcohol (3-NBA), 18-crown-6 ether, 2-nitrophenyloctyl

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rdf:type
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  • Fast Atom Bombardment (de)
  • Fast atom bombardment (en)
  • Bombardamento con atomi veloci (it)
  • 高速原子衝撃法 (ja)
  • Бомбардировка быстрыми атомами (ru)
  • 快速原子轰击 (zh)
rdfs:comment
  • 高速原子衝撃(こうそくげんししょうげき、英: Fast atom bombardment、略称: FAB)法は、質量分析において用いられるイオン化技術の一種である。分析される材料は、マトリックスと呼ばれる不揮発性化学保護環境と混合され、真空下で高エネルギー(4000〜10000電子ボルト)原子線を衝突させられる。原子は通常、アルゴンあるいはキセノンといった不活性ガスが用いられる。一般的なマトリックスとしては、グリセロールや、3-ニトロベンジルアルコール (3-NBA)、18-クラウン-6エーテル、、スルホラン、ジエタノールアミン、トリエタノールアミンがある。FAB法は二次イオン質量分析法やと似ている。 (ja)
  • Бомбардировка быстрыми атомами (англ. Fast Atom Bombardment, FAB) в масс-спектрометрии — метод ионизации полярных термически нестойких соединений. (ru)
  • 快速原子撞擊法(FAB) 是質譜分析中使用的一種電離技術,其中以高能原子束撞擊表面以產生離子。它由曼徹斯特大學的 Michael Barber 於 1980 年開發。當使用高能離子束來代替原子時(如在二次離子質譜法中),該方法稱為液體二次離子質譜法 (LSIMS)。在 FAB 和 LSIMS 中,將混合分析的材料與非揮發性化學基質,並在真空下用高能(4000 至 10,000 電子伏特)原子束撞擊。原子通常來自惰性氣體,例如氬氣或氙氣。常見的基質包括甘油、硫代甘油、3-硝基苯甲醇 (3-NBA)、18-冠-6 醚、2-硝基苯基辛基醚、環丁碸、二乙醇胺和三乙醇胺。 該技術類似於二次離子質譜和電漿體解析質譜。 (zh)
  • Fast Atom Bombardment (FAB) ist ein Ionisierungsverfahren, das in Massenspektrometern (MS) benutzt wird. Dabei wird eine Lösung des Analyts in einer flüssigen schwer-flüchtigen Matrix mit einem Partikelstrom aus gewöhnlich inerten Gasen wie Argon oder Xenon (3–8 keV) beschossen. Übliche Matrizen sind dabei Glycerin oder 3-Nitrobenzylchlorid. Diese Technik ist nahe verwandt mit der Sekundärionen-Massenspektrometrie. So spricht man von Liquid Secondary Ion Mass Spectrometry (LSIMS), wenn statt Edelgasatomen schnelle Ionen (Cs+, bis zu 35 keV) verwendet werden. (de)
  • Fast atom bombardment (FAB) is an ionization technique used in mass spectrometry in which a beam of high energy atoms strikes a surface to create ions. It was developed by Michael Barber at the University of Manchester in 1980. When a beam of high energy ions is used instead of atoms (as in secondary ion mass spectrometry), the method is known as liquid secondary ion mass spectrometry (LSIMS). In FAB and LSIMS, the material to be analyzed is mixed with a non-volatile chemical protection environment, called a matrix, and is bombarded under vacuum with a high energy (4000 to 10,000 electron volts) beam of atoms. The atoms are typically from an inert gas such as argon or xenon. Common matrices include glycerol, thioglycerol, 3-nitrobenzyl alcohol (3-NBA), 18-crown-6 ether, 2-nitrophenyloctyl (en)
  • In spettrometria di massa il bombardamento con atomi veloci è una tecnica di ionizzazione per desorbimento, simile all'. Questa tecnica produce poca frammentazione, è una tecnica di ionizzazione soft. È stata la prima tecnica per l'analisi di grandi molecole, come quelle che si incontrano in ambito biochimico, attualmente questa tecnica è in disuso. Il FAB è adatto a molecole non volatili (polari), che possono subire reazioni acido-base: glicosidi, peptidi etc. (it)
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  • http://commons.wikimedia.org/wiki/Special:FilePath/FAB_MS.jpg
  • http://commons.wikimedia.org/wiki/Special:FilePath/FAB_Schematic.jpg
  • http://commons.wikimedia.org/wiki/Special:FilePath/Fast_atom_bombardment_diagram.png
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  • Fast Atom Bombardment (FAB) ist ein Ionisierungsverfahren, das in Massenspektrometern (MS) benutzt wird. Dabei wird eine Lösung des Analyts in einer flüssigen schwer-flüchtigen Matrix mit einem Partikelstrom aus gewöhnlich inerten Gasen wie Argon oder Xenon (3–8 keV) beschossen. Übliche Matrizen sind dabei Glycerin oder 3-Nitrobenzylchlorid. Diese Technik ist nahe verwandt mit der Sekundärionen-Massenspektrometrie. So spricht man von Liquid Secondary Ion Mass Spectrometry (LSIMS), wenn statt Edelgasatomen schnelle Ionen (Cs+, bis zu 35 keV) verwendet werden. FAB ist im Vergleich zur Elektronenstoßionisation ein „sanftes“ Ionisierungsverfahren und erzeugt hauptsächlich protonierte Moleküle wie [M+H]+ oder deprotonierte Moleküle wie [M−H]−. Die Art der Ionisierungsprodukte stellt FAB in die Nähe zu Verfahren wie Chemische Ionisation (CI), Elektrospray-Ionisation (ESI), Chemische Ionisation bei Atmosphärendruck (APCI) (Atmospheric Pressure Chemical Ionization) und Matrix-unterstützte Laser-Desorption/Ionisation (MALDI) (engl. Matrix Assisted Laser Desorption/Ionization). FAB wurde ab ca. 1980 in der Routineanalytik eingesetzt. Aufgrund der geringeren Empfindlichkeit, schlechterer Ionenausbeuten und dem hohen Verschmutzungsgrad in der Ionenquelle ist dieses Ionisierungsverfahren seit Anfang 1990 durch ESI, APCI und MALDI verdrängt worden. Auch ist die Kopplung von Hochleistungsflüssigkeitschromatographie mit FAB-MS sehr viel aufwendiger und weniger effizient als die mit ESI- oder APCI-MS. (de)
  • Fast atom bombardment (FAB) is an ionization technique used in mass spectrometry in which a beam of high energy atoms strikes a surface to create ions. It was developed by Michael Barber at the University of Manchester in 1980. When a beam of high energy ions is used instead of atoms (as in secondary ion mass spectrometry), the method is known as liquid secondary ion mass spectrometry (LSIMS). In FAB and LSIMS, the material to be analyzed is mixed with a non-volatile chemical protection environment, called a matrix, and is bombarded under vacuum with a high energy (4000 to 10,000 electron volts) beam of atoms. The atoms are typically from an inert gas such as argon or xenon. Common matrices include glycerol, thioglycerol, 3-nitrobenzyl alcohol (3-NBA), 18-crown-6 ether, 2-nitrophenyloctyl ether, sulfolane, diethanolamine, and triethanolamine. This technique is similar to secondary ion mass spectrometry and plasma desorption mass spectrometry. (en)
  • 高速原子衝撃(こうそくげんししょうげき、英: Fast atom bombardment、略称: FAB)法は、質量分析において用いられるイオン化技術の一種である。分析される材料は、マトリックスと呼ばれる不揮発性化学保護環境と混合され、真空下で高エネルギー(4000〜10000電子ボルト)原子線を衝突させられる。原子は通常、アルゴンあるいはキセノンといった不活性ガスが用いられる。一般的なマトリックスとしては、グリセロールや、3-ニトロベンジルアルコール (3-NBA)、18-クラウン-6エーテル、、スルホラン、ジエタノールアミン、トリエタノールアミンがある。FAB法は二次イオン質量分析法やと似ている。 (ja)
  • In spettrometria di massa il bombardamento con atomi veloci è una tecnica di ionizzazione per desorbimento, simile all'. Questa tecnica produce poca frammentazione, è una tecnica di ionizzazione soft. È stata la prima tecnica per l'analisi di grandi molecole, come quelle che si incontrano in ambito biochimico, attualmente questa tecnica è in disuso. Comunemente si indica con FAB, dalla lingua inglese fast atom bombardment ; Consiste nel disperdere il campione in una matrice (tipicamente glicerina) su cui vengono sparati atomi pesanti ad elevata velocità. Gli atomi veloci sono prodotti dal cosiddetto cannone atomico in cui viene introdotto il gas, Ar o Xe, che per effetto di una sorgente elettronica diventano Ar+ oppure Xe+. Questi ioni vengono fatti entrare in una camera di collisione in cui è presente Argon o Xeno gassoso; gli ioni, urtando gli atomi cedono la loro energia cinetica generando così un flusso di atomi neutri che escono dalla camera di collisione ad elevata velocità ed impattano contro la matrice che contiene disperso il campione da analizzare. Alla fine della camera di collisione vi è un potenziale positivo che provvede a respingere eventuali ioni che non si siano scontrati con Xe o Ar gassoso. Il FAB è adatto a molecole non volatili (polari), che possono subire reazioni acido-base: glicosidi, peptidi etc. Lo spettro FAB forma ioni stabili: lo ione molecolare è sempre visibile ed intenso, ma spesso sono visibili anche picchi di frammentazione che possono dare utili informazioni strutturali. Questa tecnica ha però un grosso svantaggio quale il rumore di fondo sullo spettro; infatti anche la matrice ionizza e dà luogo ad un intenso picco. (it)
  • Бомбардировка быстрыми атомами (англ. Fast Atom Bombardment, FAB) в масс-спектрометрии — метод ионизации полярных термически нестойких соединений. (ru)
  • 快速原子撞擊法(FAB) 是質譜分析中使用的一種電離技術,其中以高能原子束撞擊表面以產生離子。它由曼徹斯特大學的 Michael Barber 於 1980 年開發。當使用高能離子束來代替原子時(如在二次離子質譜法中),該方法稱為液體二次離子質譜法 (LSIMS)。在 FAB 和 LSIMS 中,將混合分析的材料與非揮發性化學基質,並在真空下用高能(4000 至 10,000 電子伏特)原子束撞擊。原子通常來自惰性氣體,例如氬氣或氙氣。常見的基質包括甘油、硫代甘油、3-硝基苯甲醇 (3-NBA)、18-冠-6 醚、2-硝基苯基辛基醚、環丁碸、二乙醇胺和三乙醇胺。 該技術類似於二次離子質譜和電漿體解析質譜。 (zh)
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