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Fel d 1 is a secretoglobin protein complex that, in cats, is encoded by the CH1 (chain 1/Fel d 1-A) and CH2 (chain 2/Fel d 1-B) genes. Among cats, Fel d 1 is produced largely in their saliva and by the sebaceous glands located in their skin. It is the primary allergen present on cats and kittens. The function of the protein for cats is unknown, but it causes an IgG or IgE reaction in sensitive humans (either as an allergic or asthmatic response).

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  • Fel d 1 (en)
  • Fel d 1 (fr)
  • Fel d 1 (pt)
  • Fel d 1 (zh)
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  • Fel d 1 is a secretoglobin protein complex that, in cats, is encoded by the CH1 (chain 1/Fel d 1-A) and CH2 (chain 2/Fel d 1-B) genes. Among cats, Fel d 1 is produced largely in their saliva and by the sebaceous glands located in their skin. It is the primary allergen present on cats and kittens. The function of the protein for cats is unknown, but it causes an IgG or IgE reaction in sensitive humans (either as an allergic or asthmatic response). (en)
  • Fel d 1 est une protéine de (en) qui chez le chat est codée par les gènes CH1 (chaîne 1 / Fel d 1-A) et CH2 (chaîne 2 / Fel d 1-B). Fel d 1 est le principal allergène présent sur les chats et les chatons. Il est produit en grande partie dans la salive et les glandes sébacées du chat, et aussi par sa peau elle-même. (fr)
  • Fel d 1(Felis domesticus allergen 1)是猫的一种蛋白质,由CH2基因编码。Fel d 1主要在猫的唾液腺和皮脂腺中分泌,是存在于猫身上的主要过敏原。目前尚未清楚这种蛋白质在动物体内的作用,但它能引起敏感人群对或作出过敏反应或哮喘反应。 降低家居Fed d 1含量的可行方法有移开柔软表面(地毯)、经常洗床单、洗高效滤网和为猫洗澡。Fel d 1是一种特别粘的蛋白质,已被证明能粘在衣物和人的毛发中,而且在猫从未出现过的地方也能检测得到。 猫平均每天产生2-7微克的Fel d 1。研究也发现未被阉割的公猫的Fel d 1的产量较被阉割的公猫多,这也导致一个假设的产生,假设认为Fel d 1是由睾酮激素调控的。被阉割的公猫的Fed d 1产量和母猫相近,而未被阉割的母猫的Fel d 1的产量也与被阉割的母猫的相近。尽管母猫和被阉割的公猫的Fel d 1产量低,但也足以引发敏感人群的过敏反应。 Fel d 1是一种分子量有18 kDa的异源二聚体蛋白质。 (zh)
  • Fel d 1 é uma glicoproteína comumente presente na saliva dos gatos. Essa proteína causa uma forte reação alérgica em alguns humanos, que podem variar desde irritação no sistema respiratório até a presença de vermelhidão, coceira e descamações da pele. Além de estar presente na saliva dos gatos, a glicoproteína fel d1 também pode ser encontrada na composição do veneno produzido pelos loris, única espécie de primata venenosa conhecida. (pt)
name
  • Allergen Fel d 1, chain 1 (en)
  • Allergen Fel d 1, chain 2 (en)
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  • http://commons.wikimedia.org/wiki/Special:FilePath/Fel_d_1.png
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  • Crystallographic structure of the Fel d 1 dimer, the primary allergen present in cat saliva (en)
InterPro
  • IPR006178 (en)
  • IPR015332 (en)
Pfam
  • PF09252 (en)
Pfam clan
  • CL0370 (en)
symbol
  • Allergen_Fel_d_I_chain1 (en)
  • Feld-I_B (en)
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  • Fel d 1 is a secretoglobin protein complex that, in cats, is encoded by the CH1 (chain 1/Fel d 1-A) and CH2 (chain 2/Fel d 1-B) genes. Among cats, Fel d 1 is produced largely in their saliva and by the sebaceous glands located in their skin. It is the primary allergen present on cats and kittens. The function of the protein for cats is unknown, but it causes an IgG or IgE reaction in sensitive humans (either as an allergic or asthmatic response). (en)
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