About: Fibroblast growth factor receptor

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The fibroblast growth factor receptors (FGFR) are, as their name implies, receptors that bind to members of the fibroblast growth factor (FGF) family of proteins. Some of these receptors are involved in pathological conditions. For example, a point mutation in FGFR3 can lead to achondroplasia.

Attributes	Values
rdf:type	Thing Biomolecule Biomolecule Protein yago:WikicatTyrosineKinaseReceptors yago:BodyPart105220461 yago:Part109385911 yago:PhysicalEntity100001930 yago:Receptor105608868 protein yago:Structure105225602 yago:Thing100002452
rdfs:label	Fibroblast growth factor receptor (en) Receptor del factor de crecimiento fibroblástico (es) FGFR (fr) 線維芽細胞増殖因子受容体 (ja) Рецепторы фактора роста фибробластов (ru) 成纤维细胞生长因子受体 (zh)
rdfs:comment	The fibroblast growth factor receptors (FGFR) are, as their name implies, receptors that bind to members of the fibroblast growth factor (FGF) family of proteins. Some of these receptors are involved in pathological conditions. For example, a point mutation in FGFR3 can lead to achondroplasia. (en) Los receptores del factor de crecimiento fibroblástico o FGF-R (acrónimo de Fibroblast Growth Factor Receptor) se encuentran en el espesor de las membranas celulares y se unen de forma específica al factor de crecimiento de fibroblastos permitiéndole realizar su función. Pertenece a la superfamilia de receptores que presentan actividad tirosina quinasa intrínseca. Existen varios subtipos. Las mutaciones que alteran la estructura proteica de estos receptores pueden provocar enfermedad, por ejemplo la acondroplasia está causada por una mutación que altera el FGF-R3. (es) Les FGFR (pour « fibroblast growth factor receptors ») sont des récepteurs qui fixent les différents facteurs de croissance des fibroblastes, permettant leurs actions. (fr) 線維芽細胞増殖因子受容体（せんいがさいぼうぞうしょくいんしじゅようたい、fibroblast growth factor receptors，FGFR）は、線維芽細胞増殖因子（FGF）ファミリーのタンパク質に結合する受容体である。これらの中には疾患に関与するものがあり、例えばの点突然変異は軟骨無形成症を引き起こす可能性がある。 (ja) Рецепторы фактора роста фибробластов (англ. Fibroblast growth factor receptors; FGFR) — семейство мембранных белков, класс рецепторных тирозинкиназ, которые связываются с членами семейства факторов роста фибробластов. Мутации этих рецепторов часто приводят к нарушениям, таким как ахондроплазия. (ru) 成纤维细胞生长因子受体（英語：fibroblast growth factor receptors，FGFR）是一类与成纤维细胞生长因子结合的受体蛋白质家族，正如其名字所暗示的。这类受体涉及了一些病理条件。例如，上的一个位点突变可导致軟骨發育不全症。 (zh)
name	Fibroblast growth factor receptor (en)
dct:subject	Tyrosine kinase receptors
Wikipage page ID	5976076 (xsd:integer)
Wikipage revision ID	1022014782 (xsd:integer)
Link from a Wikipage to another Wikipage	FGF1 FGF18 FGF7 Vertebrate Ligand Point mutation Helix Achondroplasia Amino acid Dimer (chemistry) Isoform Receptor (biochemistry) Intracellular Fibroblast growth factor receptor-like 1 Tyrosine kinase receptors Acid Fibroblast growth factor Fibroblast growth factor receptor 1 Fibroblast growth factor receptor 2 Fibroblast growth factor receptor 3 Fibroblast growth factor receptor 3 FGFR3 FGFR5 Immunoglobulin Immunoglobulin superfamily Tyrosine kinase Gene splicing
Link from a Wikipage to an external page	https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi%3Fbook=gene&part=craniosynostosis https://web.archive.org/web/20100704161032/http:/www.sabiosciences.com/pathway.php%3Fsn=FGF_Signaling
sameAs	Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor receptor
dbp:wikiPageUsesTemplate	dbt:Enzymes dbt:Gene dbt:Portal_bar dbt:Reflist dbt:Short_description dbt:Growth_factor_receptor_modulators dbt:Tyrosine_kinases dbt:Growth_factor_receptors dbt:Pfam_box
InterPro	IPR016248 (en)
symbol	FGFR (en)
has abstract	The fibroblast growth factor receptors (FGFR) are, as their name implies, receptors that bind to members of the fibroblast growth factor (FGF) family of proteins. Some of these receptors are involved in pathological conditions. For example, a point mutation in FGFR3 can lead to achondroplasia. (en) Los receptores del factor de crecimiento fibroblástico o FGF-R (acrónimo de Fibroblast Growth Factor Receptor) se encuentran en el espesor de las membranas celulares y se unen de forma específica al factor de crecimiento de fibroblastos permitiéndole realizar su función. Pertenece a la superfamilia de receptores que presentan actividad tirosina quinasa intrínseca. Existen varios subtipos. Las mutaciones que alteran la estructura proteica de estos receptores pueden provocar enfermedad, por ejemplo la acondroplasia está causada por una mutación que altera el FGF-R3. (es) Les FGFR (pour « fibroblast growth factor receptors ») sont des récepteurs qui fixent les différents facteurs de croissance des fibroblastes, permettant leurs actions. (fr) 線維芽細胞増殖因子受容体（せんいがさいぼうぞうしょくいんしじゅようたい、fibroblast growth factor receptors，FGFR）は、線維芽細胞増殖因子（FGF）ファミリーのタンパク質に結合する受容体である。これらの中には疾患に関与するものがあり、例えばの点突然変異は軟骨無形成症を引き起こす可能性がある。 (ja) Рецепторы фактора роста фибробластов (англ. Fibroblast growth factor receptors; FGFR) — семейство мембранных белков, класс рецепторных тирозинкиназ, которые связываются с членами семейства факторов роста фибробластов. Мутации этих рецепторов часто приводят к нарушениям, таким как ахондроплазия. (ru) 成纤维细胞生长因子受体（英語：fibroblast growth factor receptors，FGFR）是一类与成纤维细胞生长因子结合的受体蛋白质家族，正如其名字所暗示的。这类受体涉及了一些病理条件。例如，上的一个位点突变可导致軟骨發育不全症。 (zh)
Membranome family	1201 (xsd:integer)
prov:wasDerivedFrom	wikipedia-en:Fibroblast_growth_factor_receptor?oldid=1022014782&ns=0
page length (characters) of wiki page	7934 (xsd:nonNegativeInteger)
Symbol	FGFR
foaf:isPrimaryTopicOf	wikipedia-en:Fibroblast_growth_factor_receptor
is Link from a Wikipage to another Wikipage of	Enzyme-linked receptor FGF1 FGF18 FGFR FGFR inhibitor MAPK/ERK pathway dbr:MMP2 Bladder cancer Joseph Schlessinger Pazopanib

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