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About: Flap endonuclease     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : dbo:Biomolecule, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)

Type: Biomolecule New Facet based on Instances of this Class

Flap endonucleases (FENs, also known as 5' in older references) are a class of nucleolytic enzymes that act as both 5'-3' exonucleases and structure-specific endonucleases on specialised DNA structures that occur during the biological processes of DNA replication, DNA repair, and DNA recombination. Flap endonucleases have been identified in eukaryotes, prokaryotes, archaea, and some viruses. Organisms can have more than one FEN homologue; this redundancy may give an indication of the importance of these enzymes. In prokaryotes, the FEN enzyme is found as an N-terminal domain of DNA polymerase I, but some prokaryotes appear to encode a second homologue.