State Road 500 (SR 500) is a state highway running through Florida as a mostly unsigned route under several U.S. Highways. From Chiefland to Williston it is U.S. Highway 27 Alternate (US 27 Alt.). From Williston to Ocala, it is US 27. From Ocala to Holopaw, it is US 441. From Kissimmee to Indialantic it is US 192.