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An Entity of Type : umbel-rc:DrugProduct, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)
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Fosazepam is a drug which is a benzodiazepine derivative; it is a water soluble derivative of diazepam. It has sedative and anxiolytic effects, and is a derivative of diazepam which has been substituted with a dimethylphosphoryl group to improve solubility in water.

Attributes	Values
rdf:type	Thing dul:ChemicalObject chemical substance Drug yago:WikicatBenzodiazepines yago:Agent114778436 yago:Benzodiazepine102830852 yago:CausalAgent100007347 yago:Drug103247620 yago:DrugOfAbuse103248958 yago:Matter100020827 yago:Medicine103740161 yago:MinorTranquilizer103771443 yago:MuscleRelaxant103800001 yago:PhysicalEntity100001930 yago:PsychotropicAgent104017429 yago:Relaxant104072811 drug yago:Sedative-hypnotic104166841 yago:Sedative104166553 yago:Substance100020090 yago:Tranquilizer104470232 umbel-rc:DrugProduct
rdfs:label	Fosazepam (en) Fosazepam (it)
rdfs:comment	Il fosazepam è uno psicofarmaco appartenente alla categoria delle benzodiazepine ed è considerato come un idrosolubile del Diazepam. Ha una struttura analoga a quella del diazepam, l'unica differenza è la presenza di un gruppo dimeltifosforilico per migliorarne la solubilità in acqua. (it) Fosazepam is a drug which is a benzodiazepine derivative; it is a water soluble derivative of diazepam. It has sedative and anxiolytic effects, and is a derivative of diazepam which has been substituted with a dimethylphosphoryl group to improve solubility in water. (en)
foaf:depiction
dcterms:subject	Chloroarenes GABAA receptor positive allosteric modulators Lactams Benzodiazepines
Wikipage page ID	13365521 (xsd:integer)
Wikipage revision ID	1075918225 (xsd:integer)
Link from a Wikipage to another Wikipage	Metabolite Nordiazepam Benzodiazepine Chloroarenes GABAA receptor positive allosteric modulators Lactams Elimination half-life Anxiety Anxiolytic Active metabolite Drug tolerance Drug withdrawal Nitrazepam Nordazepam Benzodiazepines Hypnotic dbr:Diazepam REM sleep Sedative Solubility Water soluble Desmethyldiazepam Benzodiazepine withdrawal
sameAs	Fosazepam Fosazepam Fosazepam Fosazepam Fosazepam Fosazepam Fosazepam Fosazepam Fosazepam
dbp:wikiPageUsesTemplate	dbt:Drugbox dbt:GABAAR_PAMs dbt:Reflist dbt:Short_description dbt:Cascite dbt:Chemspidercite dbt:Drugbankcite dbt:Fdacite dbt:Keggcite dbt:Stdinchicite dbt:Benzodiazepines
thumbnail	wiki-commons:Special:FilePath/Fosazepam.svg?width=300
ATC prefix	none (en)
c	18 (xsd:integer)
CAS number	35322 (xsd:integer)
ChemSpiderID	34056 (xsd:integer)
Cl	1 (xsd:integer)
H	18 (xsd:integer)
IUPAC name	7 (xsd:integer)
KEGG	D04248 (en)
n	2 (xsd:integer)
O	2 (xsd:integer)
p	1 (xsd:integer)
PubChem	37114 (xsd:integer)
SMILES	ClC1=CC2=CNC=O (en)
StdInChI	1 (xsd:integer)
StdInChIKey	JMYCGCXYZZHWMO-UHFFFAOYSA-N (en)
UNII	13 (xsd:integer)
verifiedrevid	455325548 (xsd:integer)
Watchedfields	changed (en)
width	190 (xsd:integer)
has abstract	Fosazepam is a drug which is a benzodiazepine derivative; it is a water soluble derivative of diazepam. It has sedative and anxiolytic effects, and is a derivative of diazepam which has been substituted with a dimethylphosphoryl group to improve solubility in water. Fosazepam has similar effects on sleep as other benzodiazepines. In a clinical trial it was reported that fosazepam to lead to increased sleep duration with less broken sleep but sleep quality was worsened with suppressed deep sleep and increased light sleep. Adverse effects included feelings of impaired morning vitality and upon discontinuing the drug benzodiazepine withdrawal symptoms of anxiety, impaired concentration and impaired morning vitality were experienced. Another clinical trial also found worsening of sleep while on benzodiazepines as well as during withdrawal with suppression of deep sleep stages including REM sleep, with increased light sleep upon withdrawal. The main metabolites of fosazepam are 3-hydroxyfosazepam and the active metabolite desmethyldiazepam which has a very long elimination half-life of about 3 days. Tolerance to the hypnotic effects of fosazepam starts to develop after about 7 days of use. Due to the very long elimination half-life of the active metabolite of fosazepam it is not recommended for use as a hypnotic. The main pharmacological effects of fosazepam may be due to its metabolite nordiazepam (desmethyldiazepam), rather than the parent drug. The long-acting active metabolite nordazepam can cause extended sedative effects at high doses or with prolonged use, and may produce residual sedation upon awakening. Fosazepam is of relatively low potency compared to other benzodiazepine derivatives, with a 100 mg dose of fosazepam equivalent to 10 mg of nitrazepam. 60 mg of fosazepam has also been estimated to be equivalent to about 5–10 mg of diazepam. Fosazepam has similar effects to nitrazepam, but with a shorter duration of action and less tendency to cause over sedation, motor-impairment, amnesia, rebound insomnia, and morning grogginess. (en) Il fosazepam è uno psicofarmaco appartenente alla categoria delle benzodiazepine ed è considerato come un idrosolubile del Diazepam. Ha una struttura analoga a quella del diazepam, l'unica differenza è la presenza di un gruppo dimeltifosforilico per migliorarne la solubilità in acqua. (it)
gold:hypernym	Drug

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