Francisco Espaillat y Virol (1734 – 1807) was a French-born surgeon, public officer, cattle rancher, and suggar, indigo and tobacco planter in the Captaincy General of Santo Domingo. As the largest slaveholder in this Spanish colony, he became one of the wealthiest men there and the ancestor of most of the present-day elite in Santiago, and the Dominican Republic elite in general, as his descendants used to marry with other upper-class families.