Francisco Mendigaña y Armendáriz (17 May 1674 – 30 October 1728) or Francisco Mendigaño Armendáriz was a Spanish-born prelate of the Roman Catholic Church. Born in Navarre, he moved to New Granada as an adult, serving in leadership positions in the Archdiocese of Bogotá. Following Archbishop Francisco del Rincón's death in 1723, he became the diocesan administrator of the archdiocese, and was appointed Archbishop of Santo Domingo in April 1726. He remained in Bogotá until 1727 or 1728, when he left for his new position in Santo Domingo, but he died along the way in 1728.