Frank B. Klepper (June 22, 1864 – August 4, 1933) was a U.S. Representative from Missouri. Born in St. John, Putnam County, Missouri, Klepper moved with his parents to Mirabile, Missouri, where he remained for ten years, and attended the common schools.He moved to Clinton County, Missouri, and engaged in agricultural pursuits.He attended Baker University, Baldwin City, Kansas, and engaged in teaching for two years. He was graduated from the law department of the University of Missouri in 1898, and was admitted to the bar the same year and commenced practice in Polo, Missouri. He served as prosecuting attorney of Caldwell County 1900-1905.