Frederic De Frouville (Virginia, c. 1850 – April 4, 1883) was an American noted for committing a murder-suicide in Washington, DC. De Frouville murdered his estranged wife, Andrea De Frouville, née Andrea Marie Wolstrup in Denmark, on April 4, 1883, and then shot and killed himself. She had legally separated from him the previous November because of his heavy drinking and abuse of her.