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About: GDF5     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:WikicatDevelopmentalGenesAndProteins, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)

Type: ThingBiomoleculegeneBiomoleculeGeneyago:Abstraction100002137yago:Arrangement107938773yago:Gene105436752yago:Group100031264yago:Ordering108456993HumanGeneproteinyago:Sequence108459252yago:Series108457976yago:WikicatDevelopmentalGenesAndProteins New Facet based on Instances of this Class

Growth/differentiation factor 5 is a protein that in humans is encoded by the GDF5 gene. The protein encoded by this gene is closely related to the bone morphogenetic protein (BMP) family and is a member of the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and osteochondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development.