German submarine U-159 was a Type IXC U-boat of Nazi Germany's Kriegsmarine built for service during World War II. The keel for this boat was laid down on 11 November 1940 at the DeSchiMAG AG Weser yard in Bremen, Germany as yard number 1009. She was launched on 1 July 1941 and commissioned on 4 October under the command of Kapitänleutnant Helmut Witte (Knight's Cross). She was sunk by an American aircraft on 28 July 1943.