Giacomo Benefatti (died 19 November 1332) was an Italian Catholic priest and professed member of the Order of Preachers who ascended to the position of Bishop of Mantua. Benefatti became noted for his tender care of the ill during epidemics of plague and both Pope Benedict XI - a close personal friend - and Pope John XXII held him in high esteem. Benefatti's reputation for personal holiness endured in the centuries after his death and the confirmation of his local 'cultus' - or popular devotion - allowed for Pope Pius IX to confirm the late bishop's beatification on 22 September 1859.