Giles Mutsekwa (14 September 1948 – 27 June 2022) was a Zimbabwean politician. He was appointed to the unity government as one of two co-ministers of Home Affairs by Prime Minister Morgan Tsvangirai in February 2009 and sworn into office on 13 February. He concurrently served as secretary for Security and Intelligence of the MDC-T, and served as MP for Mutare North from 2000 to 2008. In 2010, he was reassigned and became Minister for Housing.