Giovanni Carmazzi (born April 14, 1977) is a former American football quarterback who played in the National Football League (NFL) for two seasons with the San Francisco 49ers. He played college football at Hofstra University, where he threw for over 9,000 yards, and was selected by the 49ers in the third round of the 2000 NFL Draft. Carmazzi spent the entirety of his NFL career as a backup, never appearing in a regular season game. After being released by the 49ers, he spent one season in NFL Europe and two seasons in the Canadian Football League (CFL).