Gleich's syndrome is a rare disease in which the body swells up episodically (angioedema), associated with raised antibodies of the IgM type and increased numbers of eosinophil granulocytes, a type of white blood cells, in the blood (eosinophilia). It was first described in 1984. Gleich syndrome has a good prognosis. Attack severity may improve with steroid treatment.
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| - Gleich's syndrome (en)
- 好酸球性血管性浮腫 (ja)
- Síndrome de Gleich (pt)
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| - 好酸球性血管性浮腫（こうさんきゅうせいけっかんふしゅ、angioedema with eosinophilia）または好酸球性血管浮腫、グライヒ症候群とは、原因不詳の好酸球増多症などの症状を伴う血管性浮腫を呈する疾患のこと。未だ日本語名はないが、訳すと「好酸球増多症を伴う血管浮腫」。（薬疹として、好酸球が増多し、血管浮腫がでることがあるが、医薬品医療総合機構は「血管性浮腫」ではなく「血管浮腫」という用語を使用させている。）1984年にGleichらにより報告された血管性浮腫、好酸球増加、蕁麻疹、体重増加を繰り返す原因不明の疾患で、臓器障害を伴わない。日本では、20-30歳代の若い女性に好発する。 (ja)
- Síndrome de Gleich é uma doença rara na qual o corpo humano fica inchado episodicamente por intermédio de angioedemas, associados aos anticorpos do tipo IgM e ao crescimento aparente de granulócitos eosinófilos. Descrito pela primeira vez em 1984, tem causa desconhecida, mas não está relacionada à Síndrome de extravasamento capilar sistêmico ou à síndrome de eosinofilia-mialgia. Alguns estudos mostraram que os ataques de edema estão relacionados à exocitose, enquanto outros demonstraram anticorpos contra o endotélio.. O tratamento pode ser feito por meio de esteroides. (pt)
- Gleich's syndrome is a rare disease in which the body swells up episodically (angioedema), associated with raised antibodies of the IgM type and increased numbers of eosinophil granulocytes, a type of white blood cells, in the blood (eosinophilia). It was first described in 1984. Gleich syndrome has a good prognosis. Attack severity may improve with steroid treatment. (en)
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| - Episodic angioedema with eosinophilia (en)
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| - Gleich's syndrome is a rare disease in which the body swells up episodically (angioedema), associated with raised antibodies of the IgM type and increased numbers of eosinophil granulocytes, a type of white blood cells, in the blood (eosinophilia). It was first described in 1984. Its cause is unknown, but it is unrelated to capillary leak syndrome (which may cause similar swelling episodes) and eosinophilia-myalgia syndrome (which features eosinophilia but alternative symptoms). Some studies have shown that edema attacks are associated with degranulation (release of enzymes and mediators from eosinophils), and others have demonstrated antibodies against endothelium (cells lining blood vessels) in the condition. Gleich's syndrome is not a form of the idiopathic hypereosinophilic syndrome in that there is little or no evidence that it leads to organ damage. Rather, recent studies report that a subset of T cells (a special form of lymphocyte blood cell) found in several Gleich syndrome patients have an abnormal immunophenotype, i.e. they express CD3-, CD4+ cluster of differentiation cell surface antigens. These same aberrant T cell immunophenotypes are found in lymphocyte-variant eosinophilia, a disease in which the aberrant T cells overproduce cytokines such as interleukin 5 which simulate the proliferation of eosinophil precursor cells and are thereby responsible for the eosinophilia. It is suggested that most forms of Gleich's syndrome are due to a similar aberrant T cell mechanism and are a subtype of lymphocyte-variant eosinophilia. Gleich syndrome has a good prognosis. Attack severity may improve with steroid treatment. (en)
- 好酸球性血管性浮腫（こうさんきゅうせいけっかんふしゅ、angioedema with eosinophilia）または好酸球性血管浮腫、グライヒ症候群とは、原因不詳の好酸球増多症などの症状を伴う血管性浮腫を呈する疾患のこと。未だ日本語名はないが、訳すと「好酸球増多症を伴う血管浮腫」。（薬疹として、好酸球が増多し、血管浮腫がでることがあるが、医薬品医療総合機構は「血管性浮腫」ではなく「血管浮腫」という用語を使用させている。）1984年にGleichらにより報告された血管性浮腫、好酸球増加、蕁麻疹、体重増加を繰り返す原因不明の疾患で、臓器障害を伴わない。日本では、20-30歳代の若い女性に好発する。 (ja)
- Síndrome de Gleich é uma doença rara na qual o corpo humano fica inchado episodicamente por intermédio de angioedemas, associados aos anticorpos do tipo IgM e ao crescimento aparente de granulócitos eosinófilos. Descrito pela primeira vez em 1984, tem causa desconhecida, mas não está relacionada à Síndrome de extravasamento capilar sistêmico ou à síndrome de eosinofilia-mialgia. Alguns estudos mostraram que os ataques de edema estão relacionados à exocitose, enquanto outros demonstraram anticorpos contra o endotélio.. O tratamento pode ser feito por meio de esteroides. (pt)
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