Groß Karben station is a station at the 178.4 km mark on the Main–Weser Railway from Kassel via Marburg and Giessen to Frankfurt in the German state of Hesse. It is located approximately one kilometre from Groß Karben, now a district of Karben, and is located on the outskirts of the Karben district of Kloppenheim. Unlike the district of Groß-Karben, it is spelled without a hyphen. The station is classified by Deutsche Bahn as a category 5 station.