Guadalupe College was a private Baptist college for African Americans in Seguin, Texas. It was established in 1884 and opened officially in 1887. Its founding was chiefly due to the efforts of William B. Ball, who later became its president. David Abner Jr. was president of Guadalupe College from 1891 to 1906, a 15-year tenure during which the college flourished and gained statewide recognition. At its height during his administration, the college had an enrollment of approximately 500 students.