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(p)ppGpp, guanosine pentaphosphate and tetraphosphate, also known as the "magic spot" nucleotides, are alarmones involved in the stringent response in bacteria that cause the inhibition of RNA synthesis when there is a shortage of amino acids. This inhibition by (p)ppGpp decreases translation in the cell, conserving amino acids present. Furthermore, ppGpp and pppGpp cause the up-regulation of many other genes involved in stress response such as the genes for amino acid uptake (from surrounding media) and biosynthesis.

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  • Guanosin-3′,5′-bispyrophosphat (de)
  • Guanosina pentafosfato (es)
  • Guanosine pentaphosphate (en)
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  • Guanosin-3′,5′-bispyrophosphat, oder ppGpp ist das Signalmolekül einer bakteriellen Stressantwort, der sogenannten stringent response. Es ist ein Derivat des Guanosindiphosphats, das am 3'-Atom der Ribose eine zusätzliche Pyrophosphatgruppe trägt. ppGpp wurde zuerst in Escherichia coli entdeckt. In E. coli ist ppGpp ein Indikator für Nährstoffmangel. (de)
  • (p)ppGpp, guanosine pentaphosphate and tetraphosphate, also known as the "magic spot" nucleotides, are alarmones involved in the stringent response in bacteria that cause the inhibition of RNA synthesis when there is a shortage of amino acids. This inhibition by (p)ppGpp decreases translation in the cell, conserving amino acids present. Furthermore, ppGpp and pppGpp cause the up-regulation of many other genes involved in stress response such as the genes for amino acid uptake (from surrounding media) and biosynthesis. (en)
  • La guanosina pentafosfato, también conocida como guanosina tetafosfato o (p)ppGpp es una alarmona involucrada en las respuesta a estrés de bacterias, particularmente en los procesos de transcripción, traducción y replicación de ADN. La manera en la que estas alarmonas interactúan con estos procesos celulares puede variar entre bacterias. ​ (es)
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