Guyana competed at the 2022 Commonwealth Games at Birmingham, England from 28 July to 8 August 2022. It was the nineteenth time that Guyana is represented at the Commonwealth Games. On 5 July 2022, a team of 32 athletes (18 men and 14 women) competing in six sports was announced. Keevin Allicock and Aliyah Abrams were the country's flagbearers during the opening ceremony.