About: HLA-B46

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HLA-B46 (B46) is an HLA-B serotype. The serotype identifies the gene products of HLA-B*4601 allele.B*4601 resulted from a rare, interlocus, gene conversion between B62, probably B*1501, and a HLA-C allele. B*4601 is the most common HLA-B allele that does not have an origin within Africa, and estimated 400 million people in Eastern Asia carry a B46 allele. When found B*4601 segregates with only 2 HLA-Cw alleles, A limited number of HLA-A and HLA-DRB1 alleles suggesting that the allele recently expanded from a limited sized group within SE Asia. Extremely low frequencies outside of Eastern Asia are indicators of a recent expansion of B46 from a recently small population. The frequency distribution suggests the ancestral B46 population was in SE China, or, potentially Burma (Myanmar or Laos,

Attributes	Values
rdf:type	species yago:Abstraction100002137 yago:Allele105437785 yago:Arrangement107938773 yago:Gene105436752 yago:Group100031264 yago:Ordering108456993 yago:WikicatHLA-BAlleles yago:Sequence108459252 yago:Series108457976
rdfs:label	HLA-B46 (ar) HLA-B46 (en)
rdfs:comment	HLA-B46 هو نمط مصلي من مستضد الكريات البيضاء البشرية-ب. (ar) HLA-B46 (B46) is an HLA-B serotype. The serotype identifies the gene products of HLA-B4601 allele.B4601 resulted from a rare, interlocus, gene conversion between B62, probably B1501, and a HLA-C allele. B4601 is the most common HLA-B allele that does not have an origin within Africa, and estimated 400 million people in Eastern Asia carry a B46 allele. When found B*4601 segregates with only 2 HLA-Cw alleles, A limited number of HLA-A and HLA-DRB1 alleles suggesting that the allele recently expanded from a limited sized group within SE Asia. Extremely low frequencies outside of Eastern Asia are indicators of a recent expansion of B46 from a recently small population. The frequency distribution suggests the ancestral B46 population was in SE China, or, potentially Burma (Myanmar or Laos, (en)
foaf:depiction
dcterms:subject	HLA-B alleles
Wikipage page ID	13734284 (xsd:integer)
Wikipage revision ID	1123481885 (xsd:integer)
Link from a Wikipage to another Wikipage	Qinghai Buyei Hokkaidō Hong Kong Hui people Ulaanbaatar Polymerase chain reaction HLA-B alleles Gene conversion Gene product Naxi people Mongolia Linqu County Yunnan Paddy field HLA-A HLA-B HLA-B15 HLA-B18 HLA-B48 HLA-B55 HLA-B62 HLA-B73 HLA-C Locus (genetics) Aichi Ainu people European Bioinformatics Institute Guangxi Guangzhou Hakka people Japan Java Thai people China Maonan people Southern Min Human Genome Organisation Human leukocyte antigen HLA-DRB1 Miao people Shandong Wuhan Serotype Chromosome 6 (human) Khalkh
Link from a Wikipage to an external page	https://web.archive.org/web/20070821210135/http:/www.gene.ucl.ac.uk/nomenclature/data/get_data.php%3Fhgnc_id=4932 http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi%3FB*4601 https://www.ncbi.nlm.nih.gov/Omim/getmap.cgi%3Fchromosome=6p21.31
sameAs	HLA-B46 HLA-B46 HLA-B46 HLA-B46 HLA-B46
dbp:wikiPageUsesTemplate	dbt:Clear dbt:Reflist dbt:Technical dbt:Use_dmy_dates dbt:HLA-B_serotypes
thumbnail	wiki-commons:Special:FilePath/B46_Frequencies.png?width=300
has abstract	HLA-B46 هو نمط مصلي من مستضد الكريات البيضاء البشرية-ب. (ar) HLA-B46 (B46) is an HLA-B serotype. The serotype identifies the gene products of HLA-B4601 allele.B4601 resulted from a rare, interlocus, gene conversion between B62, probably B1501, and a HLA-C allele. B4601 is the most common HLA-B allele that does not have an origin within Africa, and estimated 400 million people in Eastern Asia carry a B46 allele. When found B*4601 segregates with only 2 HLA-Cw alleles, A limited number of HLA-A and HLA-DRB1 alleles suggesting that the allele recently expanded from a limited sized group within SE Asia. Extremely low frequencies outside of Eastern Asia are indicators of a recent expansion of B46 from a recently small population. The frequency distribution suggests the ancestral B46 population was in SE China, or, potentially Burma (Myanmar or Laos, untested). B46 in Asia correlates with wet-rice farming. The exceptions are notable, it has been found in the Nivkhi on north-eastern Sakalin Island, the Ainu, and the Nivkhi-related (genetically) Tlinglet population of Alaska at trace levels. (en)
gold:hypernym	Serotype
prov:wasDerivedFrom	wikipedia-en:HLA-B46?oldid=1123481885&ns=0
page length (characters) of wiki page	15401 (xsd:nonNegativeInteger)
foaf:isPrimaryTopicOf	wikipedia-en:HLA-B46
is Link from a Wikipage to another Wikipage of	B46 HLA-B HLA-B15 HLA-B18 HLA-B55 HLA-B73 HLA-A*02
is foaf:primaryTopic of	wikipedia-en:HLA-B46

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