About: HLA-DQ2

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-DQ3 (DQ3) is a serotype group within HLA-DQ (DQ) serotyping system. The serotype is determined by the antibody recognition of β2 subset of DQ β-chains. The β-chain of DQ is encoded by HLA-DQB1 locus and DQ2 are encoded by the HLA-DQB1*02 allele group. This group currently contains two common alleles, DQB1*0201 and DQB1*0202. HLA-DQ2 and HLA-DQB1*02 are almost synonymous in meaning. DQ2 β-chains combine with α-chains, encoded by genetically linked HLA-DQA1 alleles, to form the cis-haplotype isoforms. These isoforms, nicknamed DQ2.2 and DQ2.5, are also encoded by the DQA1*0201 and DQA1*0501 genes, respectively.

Attributes	Values
rdf:type	yago:Abstraction100002137 yago:Collection107951464 yago:Combination107963711 yago:Group100031264 yago:Haplotype105439582 yago:WikicatHLA-DQHaplotypes Band
rdfs:label	HLA-DQ2 (ca) HLA-DQ2 (en)
rdfs:comment	El HLA-DQ2 (DQ2) és un grup de serotips inclòs dins del sistema de serotips HLA-DQ (DQ). El serotip es determina a través del reconeixement dels anticossos del subconjunt β² de cadenes β de DQ. La cadena β de DQ és codificada pel locus HLA-DQB1 i els DQ2 són codificats pel grup d'al·lels HLA-DQB102. Aquest grup consta normalment de dos al·lels, DQB10201 i DQB10202. HLA-DQ2 i HLA-DQB102 tenen pràcticament el mateix significat. El DQ2 és més comú en l'Europa Occidental, el Nord i l'Est d'Àfrica. (ca) -DQ3 (DQ3) is a serotype group within HLA-DQ (DQ) serotyping system. The serotype is determined by the antibody recognition of β2 subset of DQ β-chains. The β-chain of DQ is encoded by HLA-DQB1 locus and DQ2 are encoded by the HLA-DQB102 allele group. This group currently contains two common alleles, DQB10201 and DQB10202. HLA-DQ2 and HLA-DQB102 are almost synonymous in meaning. DQ2 β-chains combine with α-chains, encoded by genetically linked HLA-DQA1 alleles, to form the cis-haplotype isoforms. These isoforms, nicknamed DQ2.2 and DQ2.5, are also encoded by the DQA10201 and DQA10501 genes, respectively. (en)
foaf:depiction
dcterms:subject	HLA-DQ haplotypes Autoimmune diseases Diabetes
Wikipage page ID	12823655 (xsd:integer)
Wikipage revision ID	1113488295 (xsd:integer)
Link from a Wikipage to another Wikipage	Sardinia Dermatitis herpetiformis HLA-DQ haplotypes Coeliac disease Glutamine Glycine Graves' disease Mongols Sjögren syndrome Diabetes mellitus type 1 Major histocompatibility complex, class II, DQ alpha 1 Autoimmune diseases Threonine HLA-DQ HLA-DQ7 HLA-DQB1 HLA-DR3 Amino acid Chromosome 6 HLA-DQ8 HLA-DQ9 HLA A1-B8-DR3-DQ2 HLA DR3-DQ2 Han Chinese Haplotype dbr:Asparagine Diabetes Kazakhstan Lambert–Eaton myasthenic syndrome Systemic lupus erythematosus Autoimmune disease Autoimmune hepatitis Phenotype Iberian Peninsula Indonesia Serine Neolithic dbr:Tissue_transglutaminase Serology MHC Class II Serotype HLA-DQA1 dbr:Wikt:allele dbr:Wikt:haplotype dbr:Wikt:cis dbr:Wikt:isoform dbr:HLA_A1-B8-DR3-DQ3 dbr:Wikt:heterodimer
sameAs	HLA-DQ2 HLA-DQ2 HLA-DQ2 HLA-DQ2 HLA-DQ2
subunit	HLA-DQB1 HLA-DQA1
dbp:wikiPageUsesTemplate	dbt:Citation_needed dbt:Color dbt:Reflist dbt:Technical dbt:PDB2 dbt:PDB dbt:HQAA dbt:HQBA dbt:DQ_serotypes dbt:Infobox_heteroisoform dbt:Gluten_sensitivity
thumbnail	wiki-commons:Special:FilePath/HLA-DQ2.5_gliadin.png?width=300
has abstract	El HLA-DQ2 (DQ2) és un grup de serotips inclòs dins del sistema de serotips HLA-DQ (DQ). El serotip es determina a través del reconeixement dels anticossos del subconjunt β² de cadenes β de DQ. La cadena β de DQ és codificada pel locus HLA-DQB1 i els DQ2 són codificats pel grup d'al·lels HLA-DQB102. Aquest grup consta normalment de dos al·lels, DQB10201 i DQB10202. HLA-DQ2 i HLA-DQB102 tenen pràcticament el mateix significat. Les cadenes β del DQ2 combinen amb les cadenes α, codificades per al·lels del HLA-DQA1 vinculats genèticament, per tal de formar les isoformes de l'haplotip cis. Aquestes isoformes, anomenades DQ2.2 i DQ2.5, també són codificades pels gens DQA10201 i DQA10501, respectivament. El DQ2 és més comú en l'Europa Occidental, el Nord i l'Est d'Àfrica. Les freqüències més elevades han estat observades en parts d'Espanya i Irlanda. Aquesta distribució té correlació amb la freqüència de dues de les malalties autoimmunitàries més prevalents. També hi ha un increment del DQB10201 en l'Àsia Central, amb valors màxims a Kazakhstan i disminuint progressivament d'oest a est cap a la Xina i, finalment, el Sud-est asiàtic. El DQ2.5 és un dels factors més predisposants per a malalties autoimmunitàries. Sovint, és codificat per un haplotip associat a un gran nombre de malalties. Aquest haplotip, conegut com a HLA A1-B8-DR3-DQ2, està associat amb malalties en les quals es sospita una implicació del HLA-DQ2. La implicació del DQ2 és segura en els casos de celiaquia. (ca) -DQ3 (DQ3) is a serotype group within HLA-DQ (DQ) serotyping system. The serotype is determined by the antibody recognition of β2 subset of DQ β-chains. The β-chain of DQ is encoded by HLA-DQB1 locus and DQ2 are encoded by the HLA-DQB102 allele group. This group currently contains two common alleles, DQB10201 and DQB10202. HLA-DQ2 and HLA-DQB102 are almost synonymous in meaning. DQ2 β-chains combine with α-chains, encoded by genetically linked HLA-DQA1 alleles, to form the cis-haplotype isoforms. These isoforms, nicknamed DQ2.2 and DQ2.5, are also encoded by the DQA10201 and DQA10501 genes, respectively. DQ2 is most common in Western Europe, North Africa and East Africa. Highest frequencies are observed in parts of Spain and Ireland; this distribution correlates with the frequency of two of the most prevalent autoimmune diseases. There is also an increase in DQB10201 in Central Asia, peaking in Kazakhstan and declining slowly west to east into China and finally Southeast Asia. DQA10501 : DQB10201. DQ2.5 is one of the most predisposing factors for autoimmune disease.DQ2.5 is encoded, often, by a haplotype associated with a large number of diseases. This haplotype, HLA A1-B8-DR3-DQ2, is associated with diseases in which HLA-DQ2 has suspect involvement. Direct involvement of DQ2 is certain in coeliac disease (also known as celiac disease). (en)
allele1b	[[#DQB1*0202 (en)
allele2b	*0202 (en)
allele3b	[[#DQB1*0201 (en)
image source	Illustration of HLA-DQ2.5 with deamidated gliadin peptide in the binding pocket. (en)
isoform	DQ α2β2 (en) DQ α3β2 (en) DQ α5β2 (en)
isoformCount	3 (xsd:integer)
isoformgroup	HLA-DQ3 (en)
nick	[[#DQ2.3 (en)

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