About: HLA-DQ8

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HLA-DQ8 (DQ8) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. DQ8 is a split antigen of the DQ3 broad antigen. DQ8 is determined by the and this generally detects the gene product of DQB1. DQ8.1 also differs from other HLA in population frequencies. Typically for MHC Class II antigens in humans, haplotype frequencies do not exceed 40%. For example, in the US the highest haplotype frequency, the haplotype that encoded DQ6.2, is around 15%, this translates into phenotype frequencies of less than 30%. Atypically haplotype frequencies exceed 40%.

Attributes	Values
rdf:type	species yago:Abstraction100002137 yago:Collection107951464 yago:Combination107963711 yago:Group100031264 yago:Haplotype105439582 yago:WikicatHLA-DQHaplotypes
rdfs:label	HLA-DQ8 (en)
rdfs:comment	HLA-DQ8 (DQ8) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. DQ8 is a split antigen of the DQ3 broad antigen. DQ8 is determined by the and this generally detects the gene product of DQB1. DQ8.1 also differs from other HLA in population frequencies. Typically for MHC Class II antigens in humans, haplotype frequencies do not exceed 40%. For example, in the US the highest haplotype frequency, the haplotype that encoded DQ6.2, is around 15%, this translates into phenotype frequencies of less than 30%. Atypically haplotype frequencies exceed 40%. (en)
foaf:depiction
dcterms:subject	HLA-DQ haplotypes Human MHC mediated diseases
Wikipage page ID	7649285 (xsd:integer)
Wikipage revision ID	1124401531 (xsd:integer)
Link from a Wikipage to another Wikipage	Rheumatoid arthritis Rio Grande Triticeae HLA-DQ haplotypes Coeliac disease ǃKung people Diabetes mellitus type 1 Type 1 diabetes HLA-DQ HLA-DQ3 HLA-DQB1 HLA-DR4 HLA Informatics Group American Diabetes Association European Bioinformatics Institute Human MHC mediated diseases Autoimmune disease Human leukocyte antigen MHC Class II Serotype HLA-DQA1 dbr:Wikt:haplotype dbr:Wikt:cis dbr:Wikt:isoform dbr:Wikt:broad_antigen dbr:Wikt:split_antigen
Link from a Wikipage to an external page	http://www.celiac.org/ http://www.celiaccenter.org/ http://www.childrenwithdiabetes.com/ http://www.coeliac.co.uk/ http://www.csaceliacs.org/ http://www.celiacawareness.org https://web.archive.org/web/20090720193635/http:/digestive.niddk.nih.gov/ddiseases/pubs/celiac/ https://web.archive.org/web/20091030082136/https:/www.diabetes.org/type-1-diabetes.jsp
sameAs	HLA-DQ8 HLA-DQ8 HLA-DQ8 HLA-DQ8
subunit	HLA-DQB1 HLA-DQA1
dbp:wikiPageUsesTemplate	dbt:Clear dbt:Clear_left dbt:Clear_right dbt:Color dbt:Reflist dbt:Technical dbt:HQAA dbt:HQBA dbt:DQ_serotypes dbt:Infobox_heteroisoform dbt:Gluten_sensitivity
thumbnail	wiki-commons:Special:FilePath/HLA-DQ8_insulin.png?width=300
has abstract	HLA-DQ8 (DQ8) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. DQ8 is a split antigen of the DQ3 broad antigen. DQ8 is determined by the and this generally detects the gene product of DQB1. DQ8 is commonly linked to autoimmune disease in the human population. DQ8 is the second most predominant isoform linked to coeliac disease and the DQ most linked to Type 1 Diabetes. DQ8 increases the risk for rheumatoid arthritis and is linked to the primary risk locus for RA, HLA-DR4. DR4 also plays an important role in Type 1 Diabetes. While the DQ8.1 haplotype is associated with disease, there is no known association with the DQB1*0305, DQ8.4 or DQ8.5 haplotypes (see infobox) with autoimmune disease; however, this may be the result of lack of study in populations that carry these and the very low frequency. DQ8.1 also differs from other HLA in population frequencies. Typically for MHC Class II antigens in humans, haplotype frequencies do not exceed 40%. For example, in the US the highest haplotype frequency, the haplotype that encoded DQ6.2, is around 15%, this translates into phenotype frequencies of less than 30%. Atypically haplotype frequencies exceed 40%. For DQ8 the highest haplotype frequencies approach 80% in parts of Central and South America and the phenotype frequencies approach 90%. This is the highest phenotype frequency observed for any DR or DQ phenotype in the human population by a wide margin. (en)
allele1b	[[#DQB1*0302 (en)
allele2b	*0302 (en)
image source	Rendering of HLA-DQ8 with immundominant insulin peptide in the binding pocket. (en)
isoform	DQ α3β8 (en)
isoformCount	2 (xsd:integer)
isoformgroup	HLA-DQ8 (en)
nick	DQ8.1v (en) [[#DQ8.1 (en)
polymer type	MHC Class II, DQ cell surface antigen (en)
rallele1b	*0302 (en)
rallele2b	*0302 (en)
rareIsoforms	2 (xsd:integer)
risoform	DQ α4β8 (en) DQ α5β8 (en)
rnick	DQ8.4 (en) DQ8.5 (en)
gold:hypernym	Serotype
prov:wasDerivedFrom	wikipedia-en:HLA-DQ8?oldid=1124401531&ns=0
page length (characters) of wiki page	67705 (xsd:nonNegativeInteger)
foaf:isPrimaryTopicOf	wikipedia-en:HLA-DQ8
is Link from a Wikipage to another Wikipage of	Monomorphic epitheliotropic intestinal T cell lymphoma Dermatitis herpetiformis Anti-apolipoprotein antibodies Anti-gliadin antibodies Anti-transglutaminase antibodies Indolent T cell lymphoproliferative disorder of the gastrointestinal tract Coeliac disease Enteropathy-associated T-cell lymphoma Major histocompatibility complex, class II, DQ alpha 1 Addison's disease Type 1 diabetes

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