Henry IV of France's wives and mistresses played a significant role in the politics of his reign. Both Henry (1553–1610) and his first wife Margaret of Valois, whom he married in 1572, were repeatedly unfaithful to each other, and the collapse of their marriage led to their estrangement and living apart. Although Henry fathered children with a series of mistresses, his lack of a legitimate heir became a cause of concern, and his marriage was not annulled until 1599. In 1600, at the age of forty-six, he married his second wife, Marie de' Medici, who bore him six children, including the future Louis XIII. Henry was unfaithful to his second wife as well and insisted that she raise his illegitimate children along with her own.