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About: Herbimycin     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : umbel-rc:ChemicalSubstanceType, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)

Type: Thingdul:ChemicalObjectchemical substanceChemical compoundyago:WikicatCarbamatesyago:WikicatMolecularFormulasyago:Abstraction100002137yago:Carbamate114792281yago:Chemical114806838yago:Communication100033020yago:Compound114818238yago:Element114840755yago:Formula106816935yago:Material114580897yago:Matter100020827yago:Message106598915yago:MolecularFormula106817173yago:Part113809207yago:PhysicalEntity100001930yago:Quinone115000973yago:Quintessence114847103yago:Relation100031921chemical compoundyago:Salt115010703yago:Statement106722453yago:Substance100019613yago:WikicatEthersyago:WikicatQuinonesumbel-rc:ChemicalSubstanceType New Facet based on Instances of this Class

Herbimycin is a benzoquinone ansamycin antibiotic that binds to Hsp90 (Heat Shock Protein 90) and alters its function. Hsp90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, angiogenesis and oncogenesis. It was originally found by its herbicidal activity, and thus named. The most recent herbimycins to be discovered, herbimycins D-F, were isolated from a Streptomyces isolated from thermal vents associated with the Ruth Mullins coal fire in Appalachian Kentucky.