Hester Site (known by the two Smithsonian trinomials 22MO569 and 22MO1011) is a major prehistoric archaeological site in Monroe County, Mississippi. It is a multicomponent site whose major occupation took place during the Archaic period with artifacts dating from 9000 to 8000 BCE, and other occupations during the Woodland and Mississippian periods. The site is one of the largest Archaic sites in the southeastern United States, and its well-stratified nature was critical in providing for accurate relative dating of finds at other sites throughout the region. The site was declared a National Historic Landmark in 2001.