About: Heterochromatin protein 1

Facets (new session)
Description
Metadata
Settings
- Rule:
- Inverse Functional Properties:
- "Same As":

About: Heterochromatin protein 1 Goto Sponge NotDistinct Permalink

An Entity of Type : umbel-rc:ProteinMolecule, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)
QRcode icon

http://dbpedia.demo.openlinksw.com/describe/?url=http%3A%2F%2Fdbpedia.org%2Fresource%2FHeterochromatin_protein_1&invfp=IFP_OFF&sas=SAME_AS_OFF

The family of heterochromatin protein 1 (HP1) ("Chromobox Homolog", CBX) consists of highly conserved proteins, which have important functions in the cell nucleus. These functions include gene repression by heterochromatin formation, transcriptional activation, regulation of binding of cohesion complexes to centromeres, sequestration of genes to the nuclear periphery, transcriptional arrest, maintenance of heterochromatin integrity, gene repression at the single nucleosome level, gene repression by heterochromatization of euchromatin, and DNA repair. HP1 proteins are fundamental units of heterochromatin packaging that are enriched at the centromeres and telomeres of nearly all eukaryotic chromosomes with the notable exception of budding yeast, in which a yeast-specific silencing complex of

Attributes	Values
rdf:type	Thing Biomolecule Biomolecule Protein yago:WikicatTranscriptionFactors yago:Abstraction100002137 yago:Beginning107290905 yago:Cause107326557 yago:Chemical114806838 yago:Compound114818238 yago:Event100029378 yago:Factor107327805 yago:Happening107283608 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Origin107323922 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:PsychologicalFeature100023100 yago:Relation100031921 yago:YagoPermanentlyLocatedEntity protein yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 umbel-rc:ProteinMolecule
rdfs:label	Heterochromatin-Protein 1 (de) Heterochromatin protein 1 (en) HP1 (ja)
rdfs:comment	Bei der Familie der Heterochromatin-Proteine 1 (HP1) (auch „Chromobox-Homolog“, CBX) handelt es sich um hochkonservierte Adaptermoleküle, die eine Vielzahl essentieller Funktionen im Zellkern übernehmen. Hierzu zählen die epigenetische Genregulation, die Aufrechterhaltung der Genomstabilität und die Ausbildung einer „Plattform“ für den Wiederaufbau der Zellkerne in der Endphase der Mitose. Erstmals beschrieben wurde es 1986 von Sarah Elgin in Drosophila melanogaster als ein Protein, welches als mutierte Form mit der Unterdrückung der Positionseffekt-Variegation verbunden ist. 1991 wurde von Prim Singh nachgewiesen, dass HP1 ein hochkonserviertes Protein des Heterochromatin ist und eine fundamentale Rolle in der epigenetischen Regulation spielt. (de) HP1（heterochromatin protein 1）ファミリーは高度に保存されたタンパク質から構成され、細胞核で重要な機能を果たす。CBX（chromobox homolog）ファミリーとも呼ばれる。その機能は、ヘテロクロマチン形成による遺伝子発現抑制、転写活性化、セントロメアへの接着複合体の結合の調節、核周縁部への遺伝子の隔離、転写の一時停止、ヘテロクロマチンの完全性の維持、1ヌクレオソームレベルでの遺伝子の抑制、ユークロマチンのヘテロクロマチン化による遺伝子抑制、DNA修復など多岐にわたる。HP1タンパク質はヘテロクロマチンのパッケージングの基本的単位であり、ほぼすべての真核生物の染色体でセントロメアとテロメアに豊富に存在する。特筆すべき例外は出芽酵母であり、酵母特異的なサイレンシング複合体であるSIR（silent information regulatory）タンパク質が同様の機能を果たしている。HP1ファミリーのメンバーはN末端のとC末端のがヒンジ領域で隔てられていることで特徴づけられる。HP1はユークロマチン領域にも存在し、その結合は遺伝子の抑制と相関している。HP1は1986年にTharappel C. JamesとSarah Elginによって、キイロショウジョウバエDrosophila melanogasterで（position-effect variegation）と呼ばれる現象に関する因子として発見された。 (ja) The family of heterochromatin protein 1 (HP1) ("Chromobox Homolog", CBX) consists of highly conserved proteins, which have important functions in the cell nucleus. These functions include gene repression by heterochromatin formation, transcriptional activation, regulation of binding of cohesion complexes to centromeres, sequestration of genes to the nuclear periphery, transcriptional arrest, maintenance of heterochromatin integrity, gene repression at the single nucleosome level, gene repression by heterochromatization of euchromatin, and DNA repair. HP1 proteins are fundamental units of heterochromatin packaging that are enriched at the centromeres and telomeres of nearly all eukaryotic chromosomes with the notable exception of budding yeast, in which a yeast-specific silencing complex of (en)
foaf:name	chromobox homolog 1 (en) chromobox homolog 3 (en) chromobox homolog 5 (en)
name	CBX5 (gene) CBX1 CBX3
dcterms:subject	Epigenetics Transcription factors
Wikipage page ID	8828948 (xsd:integer)
Wikipage revision ID	1115906649 (xsd:integer)
Link from a Wikipage to another Wikipage	Epigenetics DNA damage (naturally occurring) DNA methyltransferase DNA repair CBX5 (gene) Nucleosome Nucleosomes Epigenetics Chicken Origin recognition complex Cooperative binding Schizosaccharomyces pombe Transcription (biology) Drosophila melanogaster SFRS3 Sarah Elgin Alternative splicing Eukaryote Cell nucleus Centromere Chromodomain Chromosome Histone methyltransferase Protein Histone H1 Telomere Histone H3 Histone H4 Transcription factors Heterochromatin Homology (biology) CBX1 CBX3 dbr:Fibronectin Xenopus MECP2 Euchromatin Tetrahymena Splicing factor Chromoshadow Gene repression Position effect variegation Budding yeast
sameAs	Heterochromatin protein 1 Heterochromatin protein 1 Heterochromatin protein 1 Heterochromatin protein 1 Heterochromatin protein 1 Heterochromatin protein 1 Heterochromatin protein 1
dbp:wikiPageUsesTemplate	dbt:Citation_needed dbt:Cite_journal dbt:Main_article dbt:Refbegin

Faceted Search & Find service v1.17_git139 as of Feb 29 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 08.03.3330 as of Mar 19 2024, on Linux (x86_64-generic-linux-glibc212), Single-Server Edition (378 GB total memory, 67 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software