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Histone H3 is one of the five main histones involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the 'beads on a string' structure. Histone proteins are highly post-translationally modified however Histone H3 is the most extensively modified of the five histones. The term "Histone H3" alone is purposely ambiguous in that it does not distinguish between sequence variants or modification state. Histone H3 is an important protein in the emerging field of epigenetics, where its sequence variants and variable modification states are thought to play a role in the dynamic and long term regulation of genes.

AttributesValues
rdf:type
rdfs:label
  • Histona H3 (ca)
  • Histon H3 (de)
  • Histona H3 (es)
  • Histone H3 (en)
  • Istone H3 (it)
  • Histone H3 (fr)
  • ヒストンH3 (ja)
rdfs:comment
  • Histone H3 is one of the five main histones involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the 'beads on a string' structure. Histone proteins are highly post-translationally modified however Histone H3 is the most extensively modified of the five histones. The term "Histone H3" alone is purposely ambiguous in that it does not distinguish between sequence variants or modification state. Histone H3 is an important protein in the emerging field of epigenetics, where its sequence variants and variable modification states are thought to play a role in the dynamic and long term regulation of genes. (en)
  • ヒストンH3(英: histone H3)は、真核生物細胞のクロマチン構造に関係する5つの主要なヒストンのうちの1つである。H3は中心となる球状ドメインと長いN末端テールという特徴を持ち、ヌクレオソームの数珠玉構造に関与している。ヒストンタンパク質は高度な翻訳後修飾を受けるが、ヒストンH3は5つのヒストンのうちで最も大規模に修飾が行われる。ヒストンH3はエピジェネティクスの新興領域で重要なタンパク質であり、その配列の多様性やさまざまな修飾状態は、遺伝子の動的かつ長期的な調節に役割を果たすと考えられている。 (ja)
  • La histona H3 és una de les 5 principals histones implicades en l'estructura de les de les cèl·lules eucariotes. Amb un domini globular principal, disposa d'una llarga cua N terminal que l'involucra en l'estructura dels nucleosomes. (ca)
  • Histon H3 ist eines der fünf Haupt-Histon-Proteine des Chromatins in eukaryotischen Zellen. Bestehend aus einer globulären Hauptdomäne und einem langen N-terminalen Ende, spielt es eine Rolle in der Struktur der Nukleosomen und somit der „Perlenschnur“-Struktur der Chromatinfäden. Mutationen in der Histon H3-Proteinfamilie finden sich typischerweise in den seltenen Riesenzelltumoren des Bindegewebes und des Knochens. (de)
  • L'Histone H3 est une des 5 principales protéines histones qui sont impliquées dans la structure de la chromatine chez les cellules eucaryotes. La protéine présente un domaine principal globulaire et une longue queue N terminale et elle est un des composants du nucléosome et de la structure en « collier de perles » de la chromatine. Les protéines histones sont fortement modifiées de manière post-traductionnelle et l'histone H3 est celle qui est la plus modifiée. Le terme "Histone H3" est ambigu car il ne permet pas de discriminer les différences au niveau de la séquence ou l'état de modification de la protéine. L'Histone H3 est un acteur majeur dans le domaine de l'épigénétique car ses différents variants au niveau de la séquence et ses modifications sont impliqués dans la dynamique et la r (fr)
  • L'istone H3 è una delle cinque proteine istoniche principali che costituiscono la struttura portante dei nucleosomi e quindi della cromatina. Un dimero composto da 2 istoni H3, si combina infatti con uno composto da 2 istoni H4 a formare l'eterotetramero centrale del nucleosoma. La sua struttura consiste in un dominio globulare principale con una lunga coda N-terminale. (it)
foaf:name
  • H3 histone, family 3A (H3.3A) (en)
  • H3 histone, family 3B (H3.3B) (en)
name
  • H3 histone, family 3A (en)
  • H3 histone, family 3B (en)
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  • http://commons.wikimedia.org/wiki/Special:FilePath/Basic_units_of_chromatin_structure.svg
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