About: Homology modeling

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Homology modeling, also known as comparative modeling of protein, refers to constructing an atomic-resolution model of the "target" protein from its amino acid sequence and an experimental three-dimensional structure of a related homologous protein (the "template"). Homology modeling relies on the identification of one or more known protein structures likely to resemble the structure of the query sequence, and on the production of an alignment that maps residues in the query sequence to residues in the template sequence. It has been seen that protein structures are more conserved than protein sequences amongst homologues, but sequences falling below a 20% sequence identity can have very different structure.

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rdf:type	yago:Ability105616246 yago:Abstraction100002137 yago:Cognition100023271 yago:Know-how105616786 yago:Method105660268 yago:PsychologicalFeature100023100 yago:WikicatProteinMethods
rdfs:label	نمذجة متماثلة (ar) Homologia molecular (ca) Homologní modelování (cs) Pemodelan homologi (in) Homology modeling (en) Modélisation de protéines par homologie (fr) Modelação por homologia (pt)
rdfs:comment	A modelação por homologia de proteínas refere-se à construção de um modelo de resolução atómica de uma proteína-alvo a partir da sua sequência de aminoácidos. (pt) النمذجة المتماثلة والمعروفة أيضا باسم النمذجة المقارنة للبروتين، تشير إلى بناء نموذج ذري للبروتين «المستهدف» من تسلسل الأحماض الأمينية وبنية ثلاثية الأبعاد تجريبية لبروتين متماثل ذي صلة («القالب»). تعتمد النمذجة المتجانسة على تحديد بنية بروتينية معروفة أو أكثر يحتمل أن تشابه بنية تسلسل الاستعلام، وعلى إنتاج محاذاة تعيّن بقايا في تسلسل الاستعلام إلى بقايا في تسلسل القالب. لقد تبين أن بنى البروتين أكثر تحفظًا من متواليات البروتين بين المتجانسات، ولكن التسلسلات التي تقع تحت هوية تسلسل 20٪ يمكن أن يكون لها بنية مختلفة جدًا. (ar) L'homologia molecular, també coneguda com el modelatge comparatiu de proteïnes, es basa en la construcció d'un model tridimensional d'una proteïna diana a partir de la seva seqüència amino-acídica. Aquesta construcció es realitza mitjançant un conjunt de proteïnes que presentin una identitat en la seqüència primària major d'un 20% com per exemple, proteïnes homòlogues o que pertanyin a la mateixa família. (ca) Homologní modelování, také komparativní či knowledge-based modelování, je metoda konstrukce struktury neznámého proteinu na základě jeho aminokyselinové sekvence a na základě znalosti struktury homologního proteinu (tzv. templátu). Této metody se využívá, pokud je podobnost mezi sekvencí templátu a cílovou sekvencí dostatečně vysoká (identita alespoň 30 %), jelikož struktura proteinů bývá u homologů ze zásady konzervovanější než jejich sekvence. Struktury proteinů se sekvenční podobností menší než 20 % se však mohou významně lišit. (cs) Homology modeling, also known as comparative modeling of protein, refers to constructing an atomic-resolution model of the "target" protein from its amino acid sequence and an experimental three-dimensional structure of a related homologous protein (the "template"). Homology modeling relies on the identification of one or more known protein structures likely to resemble the structure of the query sequence, and on the production of an alignment that maps residues in the query sequence to residues in the template sequence. It has been seen that protein structures are more conserved than protein sequences amongst homologues, but sequences falling below a 20% sequence identity can have very different structure. (en) Pemodelan homologi digunakan untuk mengetahui struktur dari asam amino dengan cara membandingkan dengan sekuen yang telah diketahui strukturnya. Pemodelan homologi disebut juga dengan pemodelan komparatif yang dapat membentuk secara detail hingga struktur tiga dimensi.Proses yang dilakukan pertama adalah pensejajaran antara sekuen protein yang belum diketahui dengan semua protein yang ada dalam bank data protein. Setelah dilakukan proses persejajaran dari sekuen asam amino, maka didapatkan beberapa kandidat protein yang dari dapat dijadikan acuan. Beberapa acuan tersebut dipilih yang memiliki resolusi terbaik yang nantinya akan dijadikan cetakan.Algoritme pemodelan homologi telah dikembangkan untuk dua hal yaitu: (in) La modélisation de protéines par homologie, également connue sous le nom de modélisation comparative des protéines, se réfère à la construction d’un modèle d’une protéine « cible », dont la résolution est de niveau atomique, à partir de sa séquence d’acides aminés et d'une structure expérimentale tridimensionnelle d’une protéine homologue connexe (le « modèle »). (fr)
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dcterms:subject	Bioinformatics Protein structure Protein methods
Wikipage page ID	7026278 (xsd:integer)
Wikipage revision ID	1119159714 (xsd:integer)
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