Horton Creek is a tributary of Tunkhannock Creek in Susquehanna County and Wyoming County, in Pennsylvania, in the United States. It is approximately 11 miles (18 km) long and flows through Brooklyn Township and Lathrop Township in Susquehanna County and Nicholson Township and Nicholson in Wyoming County. The watershed of the creek has an area of 16.9 square miles (44 km2). The creek is not designated as an impaired waterbody and has no named tributaries. The topography of the creek's watershed has been described as "rough and hilly" and its channel is sinuous.