Hypoxia-inducible factor-proline dioxygenase (EC 1.14.11.29, HIF hydroxylase) is an enzyme with systematic name hypoxia-inducible factor-L-proline, 2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating). This enzyme catalyses the following chemical reaction hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2 hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2 Hypoxia-inducible factor-proline dioxygenase contains iron, and requires ascorbate.
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| - Hypoxia-inducible factor-proline dioxygenase (en)
- 缺氧誘導因子脯胺酸羥化酶 (zh)
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| - HIF脯胺酸羥化酶（英語：HIF prolyl-hydroxylase）是一個包含在缺氧誘導因子（英語：Hypoxia-inducible factor，简称：HIF）訊息路徑中的酶，也是一系列稱為HIF脯胺酸羥化酶抑制劑 治療性藥物的目標 缺氧誘導因子(HIF)是一個在演化上被保留下來的轉錄因子，它讓細胞可以針對低氧濃度環境作出生理性的反應。其中一種特定作用在HIF上的脯胺酸羥化酶已經被確認存在；而羥基化的HIF能讓蛋白質被作為降解的目標 HIF脯胺酸羥化酶已經被各式各樣抑制劑作為目標，用來治療中風，腎臟疾病缺血，贫血，和其他重大疾病。在紅血球過多症相關以及乳癌相關的PHD2突變的案例中，臨床觀察下的脯胺酸羥化酶區域突變會影響它對HIF受質的選擇性，這點對藥物設計有重要的意義。在人體中，HIF脯胺酸雙氧化酶有三種種型。分別是 PHD1、PHD2和PHD3。其中，PHD2因為它對氧氣緩慢的反應速度而被視為人體最重要的氧氣感應器。 (zh)
- Hypoxia-inducible factor-proline dioxygenase (EC 1.14.11.29, HIF hydroxylase) is an enzyme with systematic name hypoxia-inducible factor-L-proline, 2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating). This enzyme catalyses the following chemical reaction hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2 hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2 Hypoxia-inducible factor-proline dioxygenase contains iron, and requires ascorbate. (en)
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| - Hypoxia-inducible factor-proline dioxygenase (en)
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| - Hypoxia-inducible factor-proline dioxygenase (en)
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| - Hypoxia-inducible factor-proline dioxygenase (EC 1.14.11.29, HIF hydroxylase) is an enzyme with systematic name hypoxia-inducible factor-L-proline, 2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating). This enzyme catalyses the following chemical reaction hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2 hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2 Hypoxia-inducible factor-proline dioxygenase contains iron, and requires ascorbate. Hypoxia-inducible factor (HIF) is an evolutionarily conserved transcription factor that allows the cell to respond physiologically to low concentrations of oxygen. A class of prolyl hydroxylases which act specifically on HIF has been identified; hydroxylation of HIF allows the protein to be targeted for degradation. HIF prolyl-hydroxylase has been targeted by a variety of inhibitors that aim to treat stroke, kidney disease, ischemia, anemia, and other important diseases. Clinically observed prolyl hydroxylase domain mutations, as in the case of erythrocytosis- and breast cancer-associated PHD2 mutations, affect its selectivity for its HIF substrate, which has important implication for drug design. In humans, there are three isoforms of hypoxia-inducible factor-proline dioxygenase. These are PHD1, PHD2 and PHD3. PHD2, in particular, was identified as the most important human oxygen sensors due to its slow reaction with oxygen. (en)
- HIF脯胺酸羥化酶（英語：HIF prolyl-hydroxylase）是一個包含在缺氧誘導因子（英語：Hypoxia-inducible factor，简称：HIF）訊息路徑中的酶，也是一系列稱為HIF脯胺酸羥化酶抑制劑 治療性藥物的目標 缺氧誘導因子(HIF)是一個在演化上被保留下來的轉錄因子，它讓細胞可以針對低氧濃度環境作出生理性的反應。其中一種特定作用在HIF上的脯胺酸羥化酶已經被確認存在；而羥基化的HIF能讓蛋白質被作為降解的目標 HIF脯胺酸羥化酶已經被各式各樣抑制劑作為目標，用來治療中風，腎臟疾病缺血，贫血，和其他重大疾病。在紅血球過多症相關以及乳癌相關的PHD2突變的案例中，臨床觀察下的脯胺酸羥化酶區域突變會影響它對HIF受質的選擇性，這點對藥物設計有重要的意義。在人體中，HIF脯胺酸雙氧化酶有三種種型。分別是 PHD1、PHD2和PHD3。其中，PHD2因為它對氧氣緩慢的反應速度而被視為人體最重要的氧氣感應器。 (zh)
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