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About: IκB kinase     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:WikicatProteinComplexes, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)

Type: ThingBiomoleculeBiomoleculeEnzymeyago:Abstraction100002137yago:Activator114723079yago:Catalyst114723628yago:Chemical114806838yago:Cognition100023271yago:Complex105870365yago:Compound114818238yago:Concept105835747yago:Content105809192yago:Enzyme114732946yago:Idea105833840yago:Macromolecule114944888yago:Material114580897yago:Matter100020827yago:Molecule114682133yago:OrganicCompound114727670yago:Part113809207yago:PhysicalEntity100001930yago:Protein114728724yago:PsychologicalFeature100023100yago:Relation100031921enzymeyago:Substance100019613yago:Thing100002452yago:Unit109465459yago:Whole105869584yago:WikicatEnzymesOfUnknownStructureyago:WikicatProteinComplexes New Facet based on Instances of this Class

The IκB kinase (IkappaB kinase or IKK) is an enzyme complex that is involved in propagating the cellular response to inflammation. The IκB kinase enzyme complex is part of the upstream NF-κB signal transduction cascade. The IκBα (inhibitor of nuclear factor kappa B) protein inactivates the NF-κB transcription factor by masking the nuclear localization signals (NLS) of NF-κB proteins and keeping them sequestered in an inactive state in the cytoplasm. Specifically, IKK phosphorylates the inhibitory IκBα protein. This phosphorylation results in the dissociation of IκBα from NF-κB. NF-κB, which is now free, migrates into the nucleus and activates the expression of at least 150 genes; some of which are anti-apoptotic.