About: I-TASSER

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I-TASSER (Iterative Threading ASSEmbly Refinement) is a bioinformatics method for predicting three-dimensional structure model of protein molecules from amino acid sequences. It detects structure templates from the Protein Data Bank by a technique called fold recognition (or threading). The full-length structure models are constructed by reassembling structural fragments from threading templates using replica exchange Monte Carlo simulations. I-TASSER is one of the most successful protein structure prediction methods in the community-wide CASP experiments.

Attributes	Values
rdf:type	Thing software schema:CreativeWork work wikidata:Q386724 Software
rdfs:label	I-TASSER (en)
rdfs:comment	I-TASSER (Iterative Threading ASSEmbly Refinement) is a bioinformatics method for predicting three-dimensional structure model of protein molecules from amino acid sequences. It detects structure templates from the Protein Data Bank by a technique called fold recognition (or threading). The full-length structure models are constructed by reassembling structural fragments from threading templates using replica exchange Monte Carlo simulations. I-TASSER is one of the most successful protein structure prediction methods in the community-wide CASP experiments. (en)
foaf:name	I-TASSER (en)
foaf:homepage	http://zhanglab.ccmb.med.umich.edu/I-TASSER/
name	I-TASSER (en)
foaf:depiction
dcterms:subject	Structural bioinformatics software
Wikipage page ID	41452308 (xsd:integer)
Wikipage revision ID	1089099131 (xsd:integer)
Link from a Wikipage to another Wikipage	Ann Arbor University of Michigan Protein structure prediction Gene ontology Ligand Protein Data Bank CASP Enzyme commission Protein folding Binding site Bioinformatics Structural bioinformatics software Threading (protein sequence) Needleman-Wunsch algorithm Fold recognition RMSD Replica exchange Monte Carlo simulations TM-score
Link from a Wikipage to an external page	http://predictioncenter.org/ http://predictioncenter.org/casp10/groups_analysis.cgi%3Ftype=server&tbm=on&tbm_hard=on&tbmfm=on&fm=on&submit=Filter http://predictioncenter.org/casp8/groups_analysis.cgi%3Ftarget_type=0&gr_type=server&domain_classifications_id=1,2,3,4&field=sum_z_gdt_ts_server_pos http://predictioncenter.org/casp9/CD/data/html/groups.2.html http://www.predictioncenter.org/casp11/zscores_final.cgi%3Fmodel_type=first&gr_type=server_only http://www.predictioncenter.org/casp12/zscores_final.cgi%3Fmodel_type=first&gr_type=server_only https://www.predictioncenter.org/casp14/zscores_final.cgi%3Fgr_type=server_only http://zhanglab.ccmb.med.umich.edu/ http://zhanglab.ccmb.med.umich.edu/I-TASSER/ http://zhanglab.ccmb.med.umich.edu/I-TASSER/download/ http://zhanglab.ccmb.med.umich.edu/I-TASSER/download/README.txt http://zhanglab.ccmb.med.umich.edu/PSSpred/ https://www.predictioncenter.org/casp13/zscores_final.cgi%3Fmodel_type=best&gr_type=server_only https://www.youtube.com/watch%3Fv=kZGY3XgDrSA
sameAs	I-TASSER I-TASSER I-TASSER I-TASSER
dbp:wikiPageUsesTemplate	dbt:Infobox_software dbt:Reflist dbt:Unreferenced_section
thumbnail	wiki-commons:Special:FilePath/I-TASSER-pipeline.jpg?width=300
caption	I-TASSER pipeline for protein structure and function prediction. (en)
developer	Yang Zhang Lab (en)
screenshot	I-TASSER-pipeline.jpg (en)
screenshot size	275 (xsd:integer)
website	http://zhanglab.ccmb.med.umich.edu/I-TASSER/
has abstract	I-TASSER (Iterative Threading ASSEmbly Refinement) is a bioinformatics method for predicting three-dimensional structure model of protein molecules from amino acid sequences. It detects structure templates from the Protein Data Bank by a technique called fold recognition (or threading). The full-length structure models are constructed by reassembling structural fragments from threading templates using replica exchange Monte Carlo simulations. I-TASSER is one of the most successful protein structure prediction methods in the community-wide CASP experiments. I-TASSER has been extended for structure-based protein function predictions, which provides annotations on ligand binding site, gene ontology and enzyme commission by structurally matching structural models of the target protein to the known proteins in protein function databases. It has an on-line server built in the Yang Zhang Lab at the University of Michigan, Ann Arbor, allowing users to submit sequences and obtain structure and function predictions. A standalone package of I-TASSER is available for download at the I-TASSER website. (en)
gold:hypernym	Method
prov:wasDerivedFrom	wikipedia-en:I-TASSER?oldid=1089099131&ns=0
page length (characters) of wiki page	11013 (xsd:nonNegativeInteger)
foaf:isPrimaryTopicOf	wikipedia-en:I-TASSER
is Link from a Wikipage to another Wikipage of	FAM98C Proline-rich protein 30 C22orf15 List of protein structure prediction software Protein structure prediction Protein tertiary structure RNF227 G protein-coupled receptor HSH2D FAM120AOS Fam89A KIAA0825 Jeffrey Skolnick Backbone-dependent rotamer library C2orf73 C6orf136 C7orf50 CCDC180 CCDC92 CDV3 (gene) CXorf38 Isoform 1 SLC46A3 Structural bioinformatics Uncharacterized protein C15orf32
is foaf:primaryTopic of	wikipedia-en:I-TASSER

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