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About: IC-26     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : umbel-rc:DrugProduct, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)

Type: Thingdul:ChemicalObjectchemical substanceDrugyago:WikicatAminesyago:WikicatMolecularFormulasyago:WikicatSulfonatesyago:Abstraction100002137yago:AliphaticCompound114601294yago:Amine114739004yago:Chemical114806838yago:Communication100033020yago:Compound114818238yago:Formula106816935yago:Material114580897yago:Matter100020827yago:Message106598915yago:MethaneSeries114951377yago:MolecularFormula106817173yago:OrganicCompound114727670yago:Part113809207yago:PhysicalEntity100001930yago:Relation100031921drugyago:Salt115010703yago:Statement106722453yago:Substance100019613yago:Sulfonate114616410umbel-rc:DrugProduct New Facet based on Instances of this Class

IC-26 (WIN 1161-3, Methiodone) is an analogue of the opioid analgesic methadone, where the carbonyl group has been replaced by the bioisosteric sulfone group. Human and animal studies suggest that IC-26 is around the same potency as methadone, although other studies have found its activity to be inconsistent between different patients, with consistent opioid activity only being seen at a dose several times that of methadone. IC-26 was assessed for its abuse potential, but despite being found to have similar potential to methadone for development of dependence it was never placed under international control as an illegal drug.