Independence is a census-designated place and unincorporated community in Tate County, Mississippi, United States. The settlement is approximately 7 miles (11 km) south of Cockrum and 11 miles (18 km) east of Coldwater along Mississippi Highway 305. Although an unincorporated community, Independence has a zip code of 38638. It was first named as a CDP in the 2020 Census which listed a population of 200.