Inter-alpha-trypsin inhibitors (IαI) are plasma proteins consisting of three of four heavy chains selected from the group ITIH1, ITIH2, ITIH3, ITIH4 and one light chain selected from the group AMBP or SPINT2. They function as protease inhibitors. IαI form complexes with hyaluronan (HA), generating a serum-derived hyaluronan-associated protein (SHAP)-HA complex. The SHAP-HA complex is found in very high concentration in rheumatoid arthritic synovial fluid suggesting it has a role in the inflammatory response.
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| - Inhibidor de inter-alfa-tripsina (es)
- Inter-alpha-trypsin inhibitor (en)
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| - Los inhibidores de inter-alfa-tripsina (IαI) son proteínas plasmáticas formadas por de tres de las cuatro cadenas pesadas del grupo ITIH1, ITIH2, ITIH3 y ITIH4 y una cadena ligera del grupo AMBP o . Funcionan como inhibidores de la proteasa. IαI forma complejos con el hialuronano, generando un complejo de proteínas asociada a ácido hialurónico derivado del suero (SHAP-HA). El complejo SHAP-HA se encuentra en concentraciones muy altas en el líquido sinovial de pacientes con artritis reumatoide, lo que sugiere que tiene una función en la respuesta inflamatoria. (es)
- Inter-alpha-trypsin inhibitors (IαI) are plasma proteins consisting of three of four heavy chains selected from the group ITIH1, ITIH2, ITIH3, ITIH4 and one light chain selected from the group AMBP or SPINT2. They function as protease inhibitors. IαI form complexes with hyaluronan (HA), generating a serum-derived hyaluronan-associated protein (SHAP)-HA complex. The SHAP-HA complex is found in very high concentration in rheumatoid arthritic synovial fluid suggesting it has a role in the inflammatory response. (en)
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| - Los inhibidores de inter-alfa-tripsina (IαI) son proteínas plasmáticas formadas por de tres de las cuatro cadenas pesadas del grupo ITIH1, ITIH2, ITIH3 y ITIH4 y una cadena ligera del grupo AMBP o . Funcionan como inhibidores de la proteasa. IαI forma complejos con el hialuronano, generando un complejo de proteínas asociada a ácido hialurónico derivado del suero (SHAP-HA). El complejo SHAP-HA se encuentra en concentraciones muy altas en el líquido sinovial de pacientes con artritis reumatoide, lo que sugiere que tiene una función en la respuesta inflamatoria. (es)
- Inter-alpha-trypsin inhibitors (IαI) are plasma proteins consisting of three of four heavy chains selected from the group ITIH1, ITIH2, ITIH3, ITIH4 and one light chain selected from the group AMBP or SPINT2. They function as protease inhibitors. IαI form complexes with hyaluronan (HA), generating a serum-derived hyaluronan-associated protein (SHAP)-HA complex. The SHAP-HA complex is found in very high concentration in rheumatoid arthritic synovial fluid suggesting it has a role in the inflammatory response. (en)
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