The interleukin-13 receptor is a type I cytokine receptor, binding Interleukin-13. It consists of two subunits, encoded by IL13RA1 and IL4R, respectively. These two genes encode the proteins IL-13Rα1 and IL-4Rα. These form a dimer with IL-13 binding to the IL-13Rα1 chain and IL-4Rα stabilises this interaction. This IL-13 receptor can also instigate IL-4 signalling. In both cases this occurs via activation of the Janus kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) pathway, resulting in phosphorylation of STAT6. Phosphorylated STAT6 dimerises and acts as a transcription factor activating many genes, such as eotaxin.
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rdfs:label
| - Interleukin-13 receptor (en)
- Recettore dell'interleuchina-13 (it)
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rdfs:comment
| - L'IL-13 è una citochina effettrice che condivide parzialmente le vie di segnalazione con IL-4 a causa dell'utilizzo di un sistema di recettore comune (IL-4 recettore di tipo II). Un sistema recettoriale "privato", che lega specificamente l'IL13 con un'alta affinità, sembra utilizzare diverse vie di segnalazione ed è sempre più studiato per il suo interesse come nuovo potenziale fattore prognostico, biomarker o bersaglio terapeutico in diversi tipi di cancro. (it)
- The interleukin-13 receptor is a type I cytokine receptor, binding Interleukin-13. It consists of two subunits, encoded by IL13RA1 and IL4R, respectively. These two genes encode the proteins IL-13Rα1 and IL-4Rα. These form a dimer with IL-13 binding to the IL-13Rα1 chain and IL-4Rα stabilises this interaction. This IL-13 receptor can also instigate IL-4 signalling. In both cases this occurs via activation of the Janus kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) pathway, resulting in phosphorylation of STAT6. Phosphorylated STAT6 dimerises and acts as a transcription factor activating many genes, such as eotaxin. (en)
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foaf:name
| - interleukin 13 receptor, alpha 1 (en)
- interleukin 13 receptor, alpha 2 (en)
- interleukin 4 receptor (en)
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OMIM
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AltSymbols
| - IL-13R, IL13BP, CD213a2 (en)
- IL-13Ra, NR4, CD213a1 (en)
- IL4RA; CD124 (en)
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symbol
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UniProt
| - P78552 (en)
- Q14627 (en)
- Q9H186 (en)
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has abstract
| - The interleukin-13 receptor is a type I cytokine receptor, binding Interleukin-13. It consists of two subunits, encoded by IL13RA1 and IL4R, respectively. These two genes encode the proteins IL-13Rα1 and IL-4Rα. These form a dimer with IL-13 binding to the IL-13Rα1 chain and IL-4Rα stabilises this interaction. This IL-13 receptor can also instigate IL-4 signalling. In both cases this occurs via activation of the Janus kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) pathway, resulting in phosphorylation of STAT6. Phosphorylated STAT6 dimerises and acts as a transcription factor activating many genes, such as eotaxin. There is also another receptor that can bind IL-13: IL-13Rα2 encoded by the IL13RA2 gene. This binds IL-13 with very high affinity (and can therefore sequester it) but does not allow IL-4 binding. It acts as a negative regulator of both IL-13 and IL-4, however the mechanism of this is still undetermined. (en)
- L'IL-13 è una citochina effettrice che condivide parzialmente le vie di segnalazione con IL-4 a causa dell'utilizzo di un sistema di recettore comune (IL-4 recettore di tipo II). Un sistema recettoriale "privato", che lega specificamente l'IL13 con un'alta affinità, sembra utilizzare diverse vie di segnalazione ed è sempre più studiato per il suo interesse come nuovo potenziale fattore prognostico, biomarker o bersaglio terapeutico in diversi tipi di cancro. (it)
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LocusSupplementaryData
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RefSeq
| - NM_000418 (en)
- NM_000640 (en)
- NM_001560 (en)
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chromosome
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EntrezGene
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HGNCid
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RefSeq
| - NM_000418
- NM_000640
- NM_001560
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UniProt
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