About: Interleukin-13 receptor     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : umbel-rc:ProteinMolecule, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)
QRcode icon
http://dbpedia.demo.openlinksw.com/describe/?url=http%3A%2F%2Fdbpedia.org%2Fresource%2FInterleukin-13_receptor&invfp=IFP_OFF&sas=SAME_AS_OFF

The interleukin-13 receptor is a type I cytokine receptor, binding Interleukin-13. It consists of two subunits, encoded by IL13RA1 and IL4R, respectively. These two genes encode the proteins IL-13Rα1 and IL-4Rα. These form a dimer with IL-13 binding to the IL-13Rα1 chain and IL-4Rα stabilises this interaction. This IL-13 receptor can also instigate IL-4 signalling. In both cases this occurs via activation of the Janus kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) pathway, resulting in phosphorylation of STAT6. Phosphorylated STAT6 dimerises and acts as a transcription factor activating many genes, such as eotaxin.

AttributesValues
rdf:type
rdfs:label
  • Interleukin-13 receptor (en)
  • Recettore dell'interleuchina-13 (it)
rdfs:comment
  • L'IL-13 è una citochina effettrice che condivide parzialmente le vie di segnalazione con IL-4 a causa dell'utilizzo di un sistema di recettore comune (IL-4 recettore di tipo II). Un sistema recettoriale "privato", che lega specificamente l'IL13 con un'alta affinità, sembra utilizzare diverse vie di segnalazione ed è sempre più studiato per il suo interesse come nuovo potenziale fattore prognostico, biomarker o bersaglio terapeutico in diversi tipi di cancro. (it)
  • The interleukin-13 receptor is a type I cytokine receptor, binding Interleukin-13. It consists of two subunits, encoded by IL13RA1 and IL4R, respectively. These two genes encode the proteins IL-13Rα1 and IL-4Rα. These form a dimer with IL-13 binding to the IL-13Rα1 chain and IL-4Rα stabilises this interaction. This IL-13 receptor can also instigate IL-4 signalling. In both cases this occurs via activation of the Janus kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) pathway, resulting in phosphorylation of STAT6. Phosphorylated STAT6 dimerises and acts as a transcription factor activating many genes, such as eotaxin. (en)
foaf:name
  • interleukin 13 receptor, alpha 1 (en)
  • interleukin 13 receptor, alpha 2 (en)
  • interleukin 4 receptor (en)
name
dcterms:subject
Wikipage page ID
Wikipage revision ID
Link from a Wikipage to another Wikipage
sameAs
dbp:wikiPageUsesTemplate
OMIM
AltSymbols
  • IL-13R, IL13BP, CD213a2 (en)
  • IL-13Ra, NR4, CD213a1 (en)
  • IL4RA; CD124 (en)
symbol
UniProt
  • P78552 (en)
  • Q14627 (en)
  • Q9H186 (en)
has abstract
  • The interleukin-13 receptor is a type I cytokine receptor, binding Interleukin-13. It consists of two subunits, encoded by IL13RA1 and IL4R, respectively. These two genes encode the proteins IL-13Rα1 and IL-4Rα. These form a dimer with IL-13 binding to the IL-13Rα1 chain and IL-4Rα stabilises this interaction. This IL-13 receptor can also instigate IL-4 signalling. In both cases this occurs via activation of the Janus kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) pathway, resulting in phosphorylation of STAT6. Phosphorylated STAT6 dimerises and acts as a transcription factor activating many genes, such as eotaxin. There is also another receptor that can bind IL-13: IL-13Rα2 encoded by the IL13RA2 gene. This binds IL-13 with very high affinity (and can therefore sequester it) but does not allow IL-4 binding. It acts as a negative regulator of both IL-13 and IL-4, however the mechanism of this is still undetermined. (en)
  • L'IL-13 è una citochina effettrice che condivide parzialmente le vie di segnalazione con IL-4 a causa dell'utilizzo di un sistema di recettore comune (IL-4 recettore di tipo II). Un sistema recettoriale "privato", che lega specificamente l'IL13 con un'alta affinità, sembra utilizzare diverse vie di segnalazione ed è sempre più studiato per il suo interesse come nuovo potenziale fattore prognostico, biomarker o bersaglio terapeutico in diversi tipi di cancro. (it)
Arm
  • p (en)
  • q (en)
band
Chromosome
EntrezGene
HGNCid
LocusSupplementaryData
  • -q28 (en)
RefSeq
  • NM_000418 (en)
  • NM_000640 (en)
  • NM_001560 (en)
locus supplementary data
  • -q28
gold:hypernym
arm
  • p
  • q
band
  • 13.1
  • 24
  • 12.1-11.2
chromosome
  • 16
  • X
EntrezGene
  • 3566
  • 3597
  • 3598
HGNCid
  • 5974
  • 5975
  • 6015
RefSeq
  • NM_000418
  • NM_000640
  • NM_001560
UniProt
  • P78552
  • Q14627
Faceted Search & Find service v1.17_git139 as of Feb 29 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 08.03.3330 as of Mar 19 2024, on Linux (x86_64-generic-linux-glibc212), Single-Server Edition (378 GB total memory, 67 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software