About: Intramembrane protease

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Intramembrane proteases (IMPs), also known as intramembrane-cleaving proteases (I-CLiPs), are enzymes that have the property of cleaving transmembrane domains of integral membrane proteins. All known intramembrane proteases are themselves integral membrane proteins with multiple transmembrane domains, and they have their active sites buried within the lipid bilayer of cellular membranes. Intramembrane proteases are responsible for proteolytic cleavage in the cell signaling process known as regulated intramembrane proteolysis (RIP).

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rdf:type	Biomolecule yago:Abstraction100002137 yago:Activator114723079 yago:Catalyst114723628 yago:Chemical114806838 yago:Compound114818238 yago:Enzyme114732946 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 yago:WikicatEnzymes
rdfs:label	Intramembrane protease (en)
rdfs:comment	Intramembrane proteases (IMPs), also known as intramembrane-cleaving proteases (I-CLiPs), are enzymes that have the property of cleaving transmembrane domains of integral membrane proteins. All known intramembrane proteases are themselves integral membrane proteins with multiple transmembrane domains, and they have their active sites buried within the lipid bilayer of cellular membranes. Intramembrane proteases are responsible for proteolytic cleavage in the cell signaling process known as regulated intramembrane proteolysis (RIP). (en)
dcterms:subject	EC 3.4 Integral membrane proteins
Wikipage page ID	32150568 (xsd:integer)
Wikipage revision ID	1033192948 (xsd:integer)
Link from a Wikipage to another Wikipage	EC 3.4 Presenilin Enzyme kinetics Integral membrane protein Enzymes Convergent evolution Integral membrane proteins Active site Catalytic site Gamma secretase Cryo-electron microscopy Lipid bilayer Amyloid precursor protein Alzheimer's disease Eukaryote Cell membrane Cell signaling Protein complex Protease Hydrolysis Transmembrane protein Aqueous C-terminus Hydrophobic Domains of life Metalloprotease Organelle X-ray crystallography Transmembrane domain Signal peptide peptidase Scissile bond Serine protease Integral membrane proteins Peroxisome Rhomboid protease Membrane-bound transcription factor peptidase, site 2 Enzyme substrate Transmembrane helices Gamma-secretase Catalytic mechanism Aspartyl protease Glutamyl protease Site-2 protease Dennis Selkoe Membrane-bound dbr:CAAX_protein dbr:Rce1
sameAs	Intramembrane protease Intramembrane protease Intramembrane protease Intramembrane protease
dbp:wikiPageUsesTemplate	dbt:Enzymes dbt:Portal_bar dbt:Reflist dbt:Proteases
has abstract	Intramembrane proteases (IMPs), also known as intramembrane-cleaving proteases (I-CLiPs), are enzymes that have the property of cleaving transmembrane domains of integral membrane proteins. All known intramembrane proteases are themselves integral membrane proteins with multiple transmembrane domains, and they have their active sites buried within the lipid bilayer of cellular membranes. Intramembrane proteases are responsible for proteolytic cleavage in the cell signaling process known as regulated intramembrane proteolysis (RIP). Intramembrane proteases are not evolutionarily related to classical soluble proteases, having evolved their catalytic sites by convergent evolution. Although only recently discovered, intramembrane proteases are of significant research interest because of their major biological functions and their relevance to human disease. (en)
gold:hypernym	Enzymes
prov:wasDerivedFrom	wikipedia-en:Intramembrane_protease?oldid=1033192948&ns=0
page length (characters) of wiki page	12515 (xsd:nonNegativeInteger)
foaf:isPrimaryTopicOf	wikipedia-en:Intramembrane_protease
is Link from a Wikipage to another Wikipage of	Presenilin Membrane-bound transcription factor site-2 protease Archaeosortase Gamma secretase Protease HM13 ICLIP Signal peptide peptidase Serine protease Rhomboid protease Intramembrane-cleaving protease Regulated intramembrane proteolysis
is Wikipage redirect of	Intramembrane-cleaving protease Regulated intramembrane proteolysis

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